Transhydrogenase, proton-translocating

A Proton-Translocating Transhydrogenase Is a Source of Intramitochondrial NADPH... 

Proton translocating transhydrogenase (EC 1.6.1.1) found in bacteria and animal mitochondria that couples the transfer of reducing equivalents between NAD(H) and NADP(H) to the translocation of protons across the membrane, the equiKbrium being shifted toward the inner transport... 

Mercer NA, McKelvey JR, Fioravanti CF (1999) Hymenolepis diminuta catalysis of transmembrane proton translocation by mitochondrial NAD PHONAL) transhydrogenase. Exp Parasitol 91 52-58... 

Treatment with DCCD inactivates the catalytic activity of transhydrogenase as well as H -translocation activity [89]. However, the number of moles of DCCD incorporated per mole of transhydrogenase monomer varies depending on whether inactivation is related to the change in catalytic activity or proton translocation activity. Thus, a ratio of 2 was reported in the former case and one in the latter case [89]. Even though the DCCD-binding domain was proposed to be separate from the active site, DCCD inactivation was influenced by NADP(H) [89]. The conclusion... 

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