Proton-pump inhibitors gastro-oesophageal reflux

Dekel R, Morse C, Pass R. The role of proton pump inhibitors in gastro-oesophageal reflux disease. Drugs 2004 64 277-95. 

Proton pump inhibitors are widely used and possible adverse effects from very long term exposure, e.g. resistant symptoms from gastro-oesophageal reflux disease, are not yet known. 

Van Rnxteren B, Numans ME, Ponis PA, Lau J. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database Syst Rev 2000 CD002095 1-27. 

Dabholkar AH, Han C, Paris MM, Perez MC, Atkinson SN, Peura DA. The 12-month safety profile of dexlansoprazole, a proton pump inhibitor with a dual delayed release formulation, in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011 33 366-77. 

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