Proteotypic peptides

Key words Bioinformatics, Biomarker, Clinical proteomics, Proteotypic peptides, Signal transduction,... 

Proteinpedia containing over 4.8 million MS/MS spectra and 2 million peptides, it has already become an important resource for cataloging proteotypic peptides which can be used for biomarker analysis using MRM. 

Robertson Craig, J.P.C.R.C.B. (2005) The Use of Proteotypic Peptide Libraries for Protein Identification. Rapid Commun Mass Spec-trom, 19, 1844-1850. 

The results confirm that species-specific determination of proteins in archival samples is possible. Egg proteins, including yolk protein, were identified, as were proteins from sheep mUk the latter were unexpected. It is suggested that it is feasible to build a database of proteotypic peptides to more readily identify binders used in paints. 

Finally, it should be remembered that during proteomie analyses, only a fraction of genome predicted proteins and proteotypic peptides are identified and there are a number of reasons why this happens. First, peptides from undetected proteins... 

---