Proteomics drug development

Walgren JL, Thompson DC. Application of proteomic technologies in the drug development process. Toxicol Lett 2004 149 377-85. 

I. High throughput screening (Drug development) 2. DNAmicroarrays. 3. Protein microarrays. 4. Pharmacogenomics. 5. Proteomics. 

Steiner S, Wiltzman FW. Proteomics applications and opportunities in preclinical drug development. Electrophoresis 2000 21 2099-104. 

Jain, K. (2001). Proteomics delivering new routes to drug discovery, part 2. Drug Discovery Today 6(16), 829-832. Kassel, D. (2001). Combinatorial chemistry and mass spectrometry in the twenty-first century drug development laboratory. Chem. Rev. 101(2), 255-267. 

In preparing the latest edition of this textbook, I highlight the latest developments within the sector, provide a greater focus upon actual commercial products thus far approved and how they are manufactured, and I include substantial new sections detailing biopharmaceutical drug delivery and how advances in genomics and proteomics will likely impact upon (bio)pharma-ceutical drug development. 

Proteomics can make a key contribution in the identification of interacting protein partners and create a protein-protein interaction map of the cell (Lamond and Mann, 1997 Neubaer et ah, 1997 Blackstock and Weir, 1999 Link et ah, 1999). This would be of immense value to understanding the biology of the cell and can be further exploited for drug development. The simplest way to study such interaction is to purify the entire multiprotein complex by affinity-based methods. The members of the multiprotein complex can then be identified by mass spectrometry. 

INTEGRATING PROTEOMIC AND GENOMIC TOOLS TO ACCELERATE DRUG DEVELOPMENT 437... 

NCEC is supposed to be the best analytical technique in proteomic, genomic, and drug development programs due to its inherent character of nano nature. Normally, amounts of samples in these disciplines are in nanoliters, which need this sort of device. Therefore, this modality of liquid chromatography has been used for the separation and identification of various molecules in different biological matrices. 

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