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Proteomics clinical study

Many diseases are characterized by the expression of specific proteins1 in some cases, malignant cells yield unique protein profiles when total cellular protein extracts are analyzed by proteomic methods such as two-dimensional gel electrophoresis or matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS).2 High-throughput proteomic studies may be useful to differentiate normal cells from cancer cells, to identify and define the use of biomarkers for specific cancers, and to characterize the clinical course of disease. Proteomics can also be used to isolate and characterize potential drug targets and to evaluate the efficacy of treatments. [Pg.235]

The rapid progress in proteomics and peptidomics during the last decade offers us new possibilities to study clinical aspects of disorders and diseases related to the brain [1], These strategies also offer new tools to follow chemical modifications and altered metabolic disturbances that may be indicative of pathophysiological adaptations related to environmental and psychosocial prolonged stress. These techniques can contribute to developments in the diagnostic and therapeutic fields of psychiatric... [Pg.323]

See other pages where Proteomics clinical study is mentioned: [Pg.252]    [Pg.156]    [Pg.2]    [Pg.355]    [Pg.142]    [Pg.436]    [Pg.273]    [Pg.858]    [Pg.252]    [Pg.631]    [Pg.124]    [Pg.118]    [Pg.200]    [Pg.235]    [Pg.724]    [Pg.73]    [Pg.614]    [Pg.1045]    [Pg.1046]    [Pg.57]    [Pg.90]    [Pg.756]    [Pg.103]    [Pg.261]    [Pg.528]    [Pg.392]    [Pg.463]    [Pg.331]    [Pg.370]    [Pg.148]    [Pg.90]    [Pg.248]    [Pg.389]    [Pg.245]    [Pg.329]    [Pg.9]    [Pg.616]    [Pg.14]    [Pg.207]    [Pg.25]    [Pg.137]    [Pg.137]    [Pg.143]    [Pg.149]    [Pg.283]    [Pg.288]    [Pg.333]    [Pg.365]    [Pg.134]   
See also in sourсe #XX -- [ Pg.436 ]



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