Proteolytic drugs

It should be emphasised that dissolution is the dynamic process by which a material is dissolved in a solvent and is characterised by a rate (amount dissolved per time unit), while solubility is the amount of material dissolved per volume unit of a certain solvent. Solubility is often used as a short form for saturation solubility , which is the maximum amount of drug that can be dissolved at equilibrium conditions. Finally, the term intrinsic solubility is sometimes used as well, which is the solubility of the neutral form of a proteolytic drug. 

OCULAR PHARMACOKINETICS OF SOME PROTEOLYTIC DRUGS IN THE COURSE OF TOPICAL APPLICATION LONG TERM OBSERVATION... 

At present, ophthalmological clinics use some proteolytic drugs (chymotrypsin, fibrinolysin, streptase, urokinase, lekosim). Attention is drawn to these products mostly because they display fibrinolytic activity or because the use of some of them leads to lysis of hemorrhages and exudates. 

Penetration of Proteolytic Drugs, Administered by Different Methods, into Anterior Chamber Fluid... 

The anterior chamber angle in the eyes treated with proteolytic drugs differed from the one in the control group. It, unlike the latter one, was not completely filled with cells similar to fibroblasts. It was observed that fibrinous conglomerations dissipated and a delicate scar developed. 

Application of Proteolytic Drugs in Treatment of Vitreous Hemorrhages... 

Patients with intraocular hemorrhages of various etiology (267 patients but in cases with compensation of the main pathological process and in the absence of hemorrhages relapses were treated. Proteolytic drugs, when administered in therapeutic dosages (0.7 Fip in 0.2 ml of isotonic solution) by subconjunctival injection (made every other day, 5 injections per one course, treatment courses were repeated every 6 months), favored prevention of blood clots and accelerated blood resorption. 

We have worked out methods of proteolytic drug use for limiting the scarring of new ways of outflow, which were brought into being by microsurgical and laser treatment of glaucoma ... 

The macromolecular structure of drugs and the fact that relatively minor structural alterations can potentially have a major influence upon bioactivity are often complicating factors. For example, an immunoassay may be blind to the oxidation of an amino acid residue, or very limited proteolytic processing, although such events can activate or decrease bioactivity. 

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