Proteoglycan structure

FIGURE 9.34 Hyaluronate (see Figure 7.33) forms the backbone of proteoglycan structures, such as those found in cartilage. 

Kjellen, L., and Lindahl, U., 1991. Proteoglycans Structures and interactions. Annual Review of Biochemistry 60 443—475. 

FIGURE 7-26 Proteoglycan structure, showing the trisaccharide bridge. A typical trisaccharide linker (blue) connects a glycosaminoglycan—in this case chondroitin sulfate (orange)—to a Ser residue (red) in the core protein. The xylose residue at the reducing end of the linker is joined by its anomeric carbon to the hydroxyl of the Ser residue. 

Figure 2.35. Comparison between proteoglycan structures. The diagram illustrates structures of decorin (one glycosaminoglycan side chain), biglycan (two gly-cosaminoglycan side chains), proteoglycan-Lb, fibromodulin, and lumican. Also shown is the specific binding of decorin to the d and e bands on collagen fibrils.

Kresse H (1997) Proteoglycans - Structure and Functions. In Gabius H-J, Gabius S (eds) Gly-cosciences Status and Perspectives. Chapman Hall, Weinheim, p 201... 

Kjellen L, Lindahl U. Proteoglycans—structures and interactions. Annu Rev Biochem 1991 60 443-175. 

Gallagher, J.T. Lyon, M. in Proteoglycans Structure, biology and molecular interactions. lozzo, R.V., Ed. Marcel Dekker, New York, pp 2-61. 

Derivatives.—The structure of glycosaminoglycans, their binding properties with intra- and extra-cellular and cell surface components, and their biosynthesis have been reviewed. Electron microscopic studies of both intact and partially degraded proteoglycans from bovine nasal cartilage substantiate currently accepted models of proteoglycan structure. ... 

The cover illustrations depict a computer model of a proteoglycan structure, constructed by Jun-yong Choe of the Department of Biochemistry and Biophysics, Iowa State University. Teresa Larsen of The Scripps Research Institute rendered the model using AVS and custom modules created by Thomas J. Macke. 1997 by T. Larsen, TSRI. 

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