Proteins singlet oxygen oxidation

Thus, radicals are the most reactive and destructive of protein structure, followed by peroxy derivatives, singlet oxygen, and other oxygen compounds. The oxidative reactivity of some of these oxygen species is so high that just contact of the pure compound with paper or cotton fabrics can cause combustion (e.g., superoxide). 

Grune T, Klotz LO, Gieche J, Rudeck M, Sies H (2001) Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite. Free Radio Biol Med 30 1243-1253. 

Vile, G. R, and Tyrrell, R. M. 1995. UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen. Free Rad. Biol. Med. 18 721-22. 

If a large amount of the toxic substance is present, then the detoxication processes present are overwhelmed. Excess super oxide is produced, reduced GSH and NADPH are depleted, and hydroxyl radicals and singlet oxygen are formed. This is the condition known as oxidative stress (see also below this chapter). As well as causing lipid peroxidation, ROS will also cause DNA damage and damage to proteins. 

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