Proteins interact with lipid rafts

Many types of protein are known to interact with lipid rafts, in particular proteins modified by the addition of modified lipid groups, such as... 

Lipids and proteins can diffuse laterally within the plane of the membrane, but this mobility is limited by interactions of membrane proteins with internal cytoskeletal structures and interactions of lipids with lipid rafts. One class of lipid rafts consists of sphingolipids and cholesterol with a subset of membrane proteins that are GPI-linked or attached to several long-chain fatty acyl moieties. 

Fantini J. Interaction of proteins with lipid rafts through glycolipid-binding domains biochemical background and potential therapeutic applications. CurrMed Chem. 2007 14(27) 2911-2917. 

GSLs play crucial roles in functions of the nervous system and skin, cell growth and differentiation, infections, cancer, and immune response [1, 2, 12], Owing to their strategic position in membranes, they interact with toxins, bacteria, and viruses. They form membrane lipid rafts and present the attached carbohydrates as cell-surface receptors and, thus, serve as portals of entry for pathogens through carbohydrate-protein interactions [13]. For example, HIV entry is mediated by GalCer receptors of the host cells [14],... 

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