Proteins heme, reaction with nitric oxide

Reaction of nitric oxide with ferrohemoproteins produces paramagnetic NO-ligated heme proteins (S = 1/2, rhombic g tensors with principal values in the range 1.96-2.08). In many compounds studied so far by EPR the hf interaction of the NO nitrogen and of a second axial nitrogen is clearly resolved in the intermediate g-value region near... 

Sharma, V. S., Traylor, T. G., Gardiner, R., and Mizukami, H. (1987). Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. Biochemistry 26, 3837-3843. 

The primary reactions of nitric oxide are almost exclusively limited to other species possessing unpaired electrons, such as the iron in heme proteins, as well as nonheme iron and superoxide. Nitric oxide does react with molecu-... 

Sharma VS, Isaacson RA et al (1983) Reaction of nitric oxide with heme proteins studies on metmyoglobin, opossum methemoglobin, and microperoxidase. Biochemistry 22 3897-3902... 

M14. Mehl, M., Daiber, A., Herold, S., Shoun, H., and Ullrich, V., Peroxynitrite reaction with heme proteins. Nitric Oxide 3, 142-152 (199). 

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