Proteins structure analysis

Karger, B. L., and Fiancock, W. S., eds. 1996. Methods in Enzymology 271, Section III Protein Structure Analysis by Mass Sj ectrometry, f R. Yates P tide Characterization by Mass Spectrometry, B. L. Gillece-Castro and J. T. Stnlts. New York Academic Pre.s.s. 

With the development of NMR-based experiments for studying folded proteins, structural analysis of denatured proteins entered a new phase (Wuthrich, 1994 Dobson et al., 1994 Shortle, 1996). Whereas other spectroscopies and hydrodynamic studies give data that correspond to a complex sum of the properties of all residues, NMR spectroscopy extracts information about individual residues. For the first time, local structural features could be directly inferred from the behavior of sets of residues along the sequence. 

Jungblut P (1997) In Kamp RM, Choli-Papadopoulou T, Wittmann-Liebold B (eds.) Protein structure analysis. Springer, Berlin, p. 215 Kyhse-Andersen J (1984) J Biochem Biophys Meth 10 203 Towbin H, Gordon J (1984) J Immunol Meth 72 313... 

PI Kamp, R. M., Protein Structure Analysis -Preparation, Characterization and Microsequencing, Kamp, R. M. Choli-Papadopou-lou, Th. Wittmann-Liebold, B., Eds. Springer Heidelberg, (1997), p 231. 

PredictProtein Protein structure analysis Automatic sequence alignment, protein fold recognition, and secondary structure prediction web server 177 www.embl-heidelberg.de/predictprotein/... 

Insight II Program with modules for homology modeling, protein structure analysis, pharmacophore/3D-QSAR modeling, MD www.accelrys.com/insight/Insight2.html... 

The focus in proteomics is still on protein discovery and protein structure analysis rather than on dynamic proteomics and protein function. 

Bioinformatic tools are of increasing importance for the characterization of flavoenzymes. This finding holds for protein sequence and protein structural analysis as well as for gaining insight into the reactivity of the flavin cofactor by combined quantum mechanical and molecular mechanical (QM/MM) simulations (12). 

Table 1 Online resources for protein structure analysis and prediction...

Calaycay, J., Rusnak, M., and Shively, J.E. (1991) Anal. Biochem. 192, 23. Granlund-Moyer, K., Miller, C.G., and Sahakian, J.A. (1994) 10th International Conference on Methods in Protein Structure Analysis. Snowbird, Utah Sept. 8-13, Abstract L A3. 

R. M. Kamp, High sensitivity Amino add analysis, in Protein Structure Analysis (R. M. Kamp, T. Choli-Papa-dopoulou, and B. Wittman-Liebold, eds.), Springer-Verlag, Berlin, 1997. 

Guss, J.M., Bartunik, H.D., Freeman, H.C. Accuracy and precision in protein structure analysis Restrained least-squares refinement of the structure of poplar plastocyanin at 1.33 A resolution. Acta Crystallogr. B 1992, 48, 790-811. 

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