Protein-repellant coatings

We will briefly outline the principle thermodynamic considerations that comprise the underlying key issues of protein adsorption on surfaces. Subsequently, we will describe strategies that have been followed for the design of protein-repellent surface coatings. For details on protein adsorption, as well as further discussion on this particular topic, the reader is referred to more comprehensive reviews [31, 32],... 

Many approaches comprise some attractive features with respect to specific binding to certain integrins and long-term stability of the produced surface coatings. In order to ensure the exclusive interaction of the cells with the recognition sites presented (and not with unspecifically adsorbed proteins), the matrix (i.e., the background) must possess protein-repellent properties. 

Chem. Descrip. Chrome complex sol n. in IPA Uses Water repellent, release agent used on paper/paperboard for water-repellent pkg. materials, food pkg., grease-resistant and release paper when used with PVA, water-repellent coatings and adhesives, water- and stain-resistant leather (shoes, golf bags, etc.), colorfast, water-repellent suede (dry-cleanable) insolubilizer for adhesives, films, protein binders, and inks... 

Besides the numerous synthetic and natural polymers that are suited for repelling microbes from surfaces (summarized in [8]), the negatively charged protein albumin can also reduce bacterial adhesion [30], Further, the nature of the surface-attached repelling polymer and its mechanical properties both seem to play a role in the attraction of microbes. This was demonstrated by Lichter et al., who investigated poly(allylammonium hydrochloride) (PAH) and poly(acrylic acid) (PAA) multilayers and found that the stiffness of the coating positively correlated with the adhesion of E. coli. [31],... 

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