Protein oxidative change

Most frequently, SEC with dextran-, pullulan-, or polystyrene calibration standards has been used to characterize the molecular properties of xylans. However, as for viscometric studies [108], a sufficient solvent ionic strength is a prerequisite for useful SEC measurements of charged polysaccharides, including glucuronoxylans [111-113]. An advantage of the SEC technique is that the presence of protein and phenolic components or oxidative changes can be detected by simultaneous ultraviolet (UV) detection. 

Quinlan, G.J., Evans, T.W. and Gutteridge, J.M.C. (1994). Linoleic acid and protein thiol changes suggestive of oxidative damage in the plasma of patients with adult respiratory distress syndrome. Free Bad. Res. Commun. 20, 299-306. 

All these genetic factors may interact in still-unknown genetic networks, leading to a cascade of pathogenic events characterized by abnormal protein processing and misfolding with snbseqnent accnmnlation of abnormal proteins (conformational changes), nbiqnitin-proteasome system dysfunction, excitotoxic reactions, oxidative... 

Protein Oxidation State Change Edge Shift (eV) Ligand vs. Metal Redox References... 

Overall, from the data presented above it is clear that oxidation of specific brain proteins alters the structure and thereby function of the proteins. Such changes could be important in AD pathology. 

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