Protein macrosystem

The single protein with its hydration shell will be referred to as the protein-microsystem , while the collective sum of protein microsystems will be addressed as the protein-macrosystem . 

Thus, the enthalpy Hp of the protein-macrosystem can be obtained, if the enthalpy of the protein solution, H, and the enthalpy of the pure buffer, Hb, can be determined. The enthalpy value Hp corresponds to an ensemble average of the protein-macrosystem. Due to ergodicity the value is also equivalent to the time average behaviour the single protein-microsystem [19]. Therefore we may drop the differentiation between the... 

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