Protein Glutathionylation as a Regulatory Response

Mitochondrial membrane permeability transition and its role in the mechanism of toxicity of many chemicals is a major area of research focus. The protein thiol status of mitochondria is crucial to the control of the inner-membrane potential for ATP synthesis and the membrane permeability transition as well as cellular integrity. Protein thiols appear to have a major role in signal transduction and are important in the responses to chemical exposure. 

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