Protein-glass transition and hydration-layer dynamics

5 Protein-glass transition and hydration-layer dynamics 

Biological activity is found to be restored after the protein-glass transition [8]. The protein-glass transition appears to be a general phenomenon at low temperature in hydrated proteins. 

Several studies have explored the relationship between a possible dynamic transition in supercooled water and a transition in glass. The issue, however, is complicated. In bulk water, indirect evidence (such as extrapolation of experimental results at 260 K and simulations with various force fields) suggests the occurrence of a stmctural transformation in the supercooled liquid around 220 K. 

Computer simulations identify sueh a transformation with a liquid-liquid transition where the usual liquid, now ealled high-density liquid (HDL), at high 

Bulk liquid water is also believed to undergo a glass transition in the temperature range 160-180 K, but this is also not clearly established. 

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