Protein farnesyltransferase

Lane KT, Beese LS (2006) Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res 47 681-699... 

Park HW et al (1997) Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. Science 275(5307) 1800-1804... 

Protein farnesyltransferase (PFT) is responsible for farnesylation of cellular proteins, and PFT inhibitors have recently been developed for treatment of diseases involving farnesylated proteins. 

Chen, W.J., Moomaw, J.F., Overton, L., Kost, T.A., and Casey, P.J. (1993). High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. J Biol Chem 268 9675-9680. 

Reiss, Y., Brown, M.S., and Goldstein, J.L. (1992). Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. J Biol Chem 267 6403-6408. 

Long, S.B., Casey, P.J., and Beese, L.S. (1998). Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. Biochemistry 37 9612-9618. 

Yokoyama, K., Zimmerman, K., Scholten, J., and Gelb, M.H. (1997). Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation. J Biol Chem 272 3944-3952. 

Bowers, K.E., and Fierke, C. A. (2004). Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group. Biochemistry 43 5256-5265. 

Huang, C., Hightower, K.E., and Fierke, C.A. (2000). Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. Biochemistry 39 2593-2602. 

Hougland, J.L., Hicks, K.A., Hartman, H.L., Kelly, R.A., Watt, T.J., and Fierke, C.A. (2010). Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. J Mol Biol 395 176-190. 

Tschantz, W.R., Furfine, E.S., and Casey, P.J. (1997). Substrate binding is required for release of product from manunalian protein farnesyltransferase. J Biol Chem 272 9989-9993. 

Huang, C.C., Casey, P.J., and Fierke, C. A. (1997). Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2h—farnesyltransferase indicates metal coordination of the substrate thiolate. J Biol Chem 272 20-23. 

Rozema, D.B., and Poulter, C.D. (1999). Yeast protein farnesyltransferase. pKas of peptide substrates bound as zinc thiolates. Biochemistry 38 13138-13146. 

Dolence, J.M., and Poulter, C.D. (1995). A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase. Proc Natl Acad Sci USA 92 5008-5011. 

Yang, S.H., et al. (2005). Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci USA 102 10291-10296. 

Pickett, J.S., et al. (2003). Kinetic studies of protein farnesyltransferase mutants estabhsh active substrate conformation. Biochemistry 42 9741-9748. 

Overhand, M., et al. (1998). Inhibitors of protein farnesyltransferase and protein geranyl-geranyl transferase I Synthesis of homologous diphosphonate analogues of isoprenylated pyrophosphate. Bioorg Chem 26 269-282. 

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