Geranylgeranyltransferase type

Lane KT, Beese LS (2006) Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res 47 681-699... 

Taylor JS et al (2003) Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J 22(22) 5963—5974... 

Nishimura S, Matsunaga S, Shibazaki M, Suzuki K, Furihata K, van Soest RWM, Fusetani N (2003) Massadine, a Novel Geranylgeranyltransferase Type I Inhibitor from the Marine Sponge Stylissa aff. massa. Org Lett 5 2255... 

Zhang, F.L., Moomaw, J.F., and Casey, P.J. (1994). Properties and kinetic mechanism of recombinant mammahan protein geranylgeranyltransferase type I. J Biol Chem 269 23465-23470. 

Stirtan, W.G., and Poulter, C.D. (1995). Yeast protein geranylgeranyltransferase type I overproduction, purification, and characterization. Arch Biochem Biophys 321 182-190. 

The first step of the series of modifications involved in the processing of CAAX-type prenyl proteins occurs in the cytoplasm, catalyzed by either protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I). The specificity for either of these two enzymes for the most part depends on the identity of the last amino acid X of the CAAX consensus sequence. When X is serine, cysteine, alanine, or glutamine, the 15 carbon farnesyl group is added to the cysteine catalyzed by FTase and when X is leucine, the 20 carbon geranylgeranyl group is added by... 

Khan, O.M., et al. (2011). Geranylgeranyltransferase type I (GGTase-I) deficiency hyper-activates macrophages and induces erosive arthritis in mice. J Clin Invest 121 628-639. 

S, Q, A, or C, whereas GGTase-I recognizes CaaX boxes with X = L or F. Other prenylated proteins, such as the Rab proteins involved in vesicular transport, terminate in a CC, CXC, or CC(X) , 3 motif these proteins are substrates for protein geranylgeranyltransferase type II (GGTase-II) [3]. In order to be prenylated, Rab proteins must associate with Rab escort protein after geranylgeranylation, Rab escort protein delivers the prenylated Rab to membranes. 

Nishimura, S., Matsunaga, S., Shibazaki, M., Suzuki, K Harada, N., Naoki, H., and Fusetani, N. (2002) Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type 1 inhibitors, from the marine sponge Petrosia corticata. J. Nat. Prod., 65,1353-1356. 

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