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Protein family landscapes

Structure-Based Chemogenomics Analysis of Protein Family Landscapes 283... [Pg.283]

Naumann, T. and Matter, H. (2002) Structural classification of protein kinases using 3d molecular interaction field analysis of their ligand binding sites Target family landscapes../. Med. Chem. 45, 2366-2378. [Pg.374]

Naumann and Matter used a set of 26 X-ray structures of eukaryotic protein kinases, which were classified into subfamilies with similar protein-ligand interactions in the ATP binding site. As can be seen in Fig. 3.13, which shows the GPGA score plot, PC 1 separates CDK and MAP/receptor kinases on the left from the family of PKA kinases. The CDK family is represented by two distinct clusters in the target family landscape, formed by two different ATP binding site conformations. They correspond to the activated and inactivated kinase conformations... [Pg.69]

B. Pirard, Peroxisome proliferator-acti-vated receptors target family landscape A chemometrical approach to ligand selectivity based on protein binding site analysis,/. Comput.-Aided Mol. Des. [Pg.80]

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See also in sourсe #XX -- [ Pg.5 , Pg.57 , Pg.281 , Pg.293 ]



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