Protein CSPs involved with

Different classifications for the chiral CSPs have been described. They are based on the chemical structure of the chiral selectors and on the chiral recognition mechanism involved. In this chapter we will use a classification based mainly on the chemical structure of the selectors. The selectors are classified in three groups (i) CSPs with low-molecular-weight selectors, such as Pirkle type CSPs, ionic and ligand exchange CSPs, (ii) CSPs with macrocyclic selectors, such as CDs, crown-ethers and macrocyclic antibiotics, and (iii) CSPs with macromolecular selectors, such as polysaccharides, synthetic polymers, molecular imprinted polymers and proteins. These different types of CSPs, frequently used for the analysis of chiral pharmaceuticals, are discussed in more detail later. 

There is clear evidence for the involvement of three sporozoite-expressed proteins in the invasion of the salivary glands CSP, TRAP, MAEBL and four members of the LAP (LCCL/lectin adhesive-like protein family) (Raine et al., 2007) involved in sporozoite development. CSP, encoded by a single copy gene, is not found in any other apicomplexan and has been the target of many vaccine studies. CSP, is the major surface protein of the sporozoite, forming a dense coat on the parasite surface. It is presumably secreted by the apical organelles, has a signal peptide, a central domain with many amino acid repeats and a C-terminal... 

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