Protein-based materials synthesized

Designed and synthesized protein-based materials have the potential to restore and sustain individual health and societal health. 

Biocompatibility of Chemically Synthesized Protein-based Materials... 

Recently, Murthy et al. have synthesized an acid-sensitive microgel material for the development of protein-based vaccines. The chemical design of these microgels is such that they degrade under the mildly acidic conditions found in the phago-... 

D.W. Urry, D.T. McPherson, J. Xu, H. Daniell, C. Guda, D.C. Gowda, N. Jing,T.M. Parker, Protein-based Polymeric Materials Syntheses and Properties. In The Polymeric Materials Encyclopedia Synthesis, Properties and Applications, CRC Press, Boca Raton, pp. 7263-7279,1996. 

As introduced in Chapter 1, the present chapter constitutes Assertion 4 The Applications Assertion of the book. Production and purification are first addressed, as they obviously make up the initial enabling steps in moving toward applications of any materials. The most surefooted path toward materials applications of protein-based polymers, however, intertwines issues of production and purification through a combination of the two methods of preparation—chemical synthesis and biosynthesis. Chemical synthesis proved the biocompatibility of elastic protein-based polymers and therefore opened the door to medical applications. Demonstration of the biocompatibility of the chemically synthesized product made clear the purification required of elastic protein-based polymers produced by E. coli if unlimited medical applications were to be possible. Chemical synthesis also provided a faster route to diverse polymer compositions, which allowed... 

In contrast to high density arrays low density arrays are made by deposition of pre-synthesized oligonucleotides or proteins on activated surfaces. There are several printing techniques for fabricating microarrays Non-contact biochip arrayers, commonly based on the piezoelectric effect, can apply controlled sub-nanoliter probe volumes to pre-specified locations on the chip surface. Due to the fact that the dispenser does not touch the surface, a non-contact arrayer provides low risk of contamination and is most suitable for printing on soft materials such as hydrogels. 

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