Protective Role of Ascorbic Acid against Neurological Disorders

PROTECTIVE ROLE OF ASCORBIC ACID AGAINST NEUROLOGICAL DISORDERS 

The last section of this review discusses the possible roles of ascorbic acid in the disease states of the nervous system. Mental depression is the first symptom of scurvy, although the half-life of ascorbic acid during depletion in the brain is the longest of all tissues (Pelletier, 1969 Hodges et al., 1971). The appearance of this symptom may be relevant to the interactions of ascorbic acid with dopamine and/or other monoamine neurotransmitter systems (Section 4). 

There is ample evidence that ascorbic acid is neuroprotective in several models of brain damage. Since in vitro and in vivo models have distinct properties, they are discussed separately below. 

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