Protective antigen identification

Harrison, G.B.L., Heath, D.D., Dempster, R.P., Lawrence, S.B., Lightowlers, M.W. and Rickard, M.D. (1993) Identification of host-protective antigens of Taenia ovis oncospheres. International journal for Parasitology 23, 41-50. 

Harrison, L. J. S. Parkhouse, R. M. E. (1986). Identification of protective antigens in Taenia saginata cysticercosis. Coopers Animal Health Symposium on the immunobiology and molecular biology of cestode infections. Abstract A2. University of Melbourne, Veterinary School Melbourne. 

Benson, E.L., Huynh, P.D., Finkelstein, A., Collier, R.J. (1998). Identification of residues lining the anthrax protective antigen channel. Biochemistry 37 3941-8. 

ELLIS, A.E., BURROWS, A.S., HASTINGS, T.s. and STAPLETON, K.J. (1988) Identification of Aeromonas salmonicida extracellular proteases as a protective antigen against furunculosis by passive immunization. Aquaculture 70,207-218. 

The remarkable success that has been achieved with identification of protective, recombinant antigens against the Taenia and Echinococcus species has been in stark contrast to the general lack of success that has been achieved with vaccine development against other parasitic helminth infections (Dalton and Mulcahy, 2001). Hence, very little direction has been available from the experiences of others on how to translate a laboratory success with an anti-parasite vaccine into a practical (commercial) vaccine. First principles would suggest a host of issues that require investigation/opti-mization, for example ... 

Precise definition of the host-protection epitope(s) of the Taenia and Echinococcus vaccine antigens would be valuable if it were to lead to the development of a synthetic vaccine or provide reagents to assist with quality control of vaccine production. Identification of a limited number of host-protective fragments may allow the recombinant antigen to be replaced by synthetic peptides. This would have significant advantages in the production... 

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