Protease inhibitors Etoposide

Pharmacokinetic studies in dogs demonstrated a 3.5-fold increase in oral bioavailability of phenytoin when administered as the disodium phosphate prodrug versus sodium phenytoin [54]. A few additional examples of investigations with this strategy include the steroids betamethasone [55] and hydrocortisone [56], HIV protease inhibitors [57], and the anticancer drug etoposide [58,59]. Comprehensive reviews of this strategy are also available [52,60,61]. 

Anticancer drugs etoposide, doxorubicin, vincristine Ca + channel blockers dUtiazem, verapamil HIV protease inhibitors indinavir, ritonavir Antibiotics/antifungals erythromycin, ketoconazole Hormones testosterone, progesterone Immunosuppressants cyclosporine, FK506 (tacrolimus)... 

Characteristics Nucleotide analogues Anticancer drugs 6-mercaptopurine Cyclic nucleotides cyclic AMP, cyclic GMP HIV protease inhibitors adefovir Anticancer drugs doxorubicin, etoposide ... 

Use of protease inhibitor-based regimens has been found to be associated with a higher incidence of infections and neutropenia in patients receiving cyciophosphamide, doxorubicin and etoposide (CDE) than use of a NNRTI-based regimen. 

---