Proteases in blood clotting

Plasmin, fibrinolysin, a serine protease catalyzing Lys-Xaa and Arg-Xaa bond cleavage similar to that of trypsin. Plasmin is the key protease in blood clot lysis, and its major natural substrates are fibrinogen and fibrin. Human plasmin is derived from plasminogen, and is a two-chain protein consisting of the A or H chain (Mr 65 kDa) and the B or L chain (Mr 27.7 kDa). The active site is located in the B chain. The various molecular forms of plasmin are inactivated by protein inhibitors such as the Kunitz type, serpins, soybean and limabean trypsin inhibitors. The most important, fast-acting inhibitor of plasmin... 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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