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Prosthetic centers

To successfully describe the structure and function of nitrogenase, it is important to understand the behavior of the metal-sulfur clusters that are a vital part of this complex enzyme. Metal-sulfur clusters are many, varied, and usually involved in redox processes carried out by the protein in which they constitute prosthetic centers. They may be characterized by the number of iron ions in the prosthetic center that is, rubredoxin (Rd) contains one Fe ion, ferredoxins (Fd) contain two or four Fe ions, and aconitase contains three Fe ions.7 In reference 18, Lippard and Berg present a more detailed description of iron-sulfur clusters only the [Fe4S4] cluster typical of that found in nitrogenase s Fe-protein is discussed in some detail here. The P-cluster and M center of MoFe-protein, which are more complex metal-sulfur complexes, are discussed in Sections 6.5.2. and 6.5.3. [Pg.239]

As mentioned in Sect. 5.3.3, a number of enzymes contain metal ions that participate in the catalytic reaction. Two specialized databases store information on metal ions and other bioinorganic motifs in enzymes. PROMISE (prosthetic centers and metal ions in protein active sites) is maintained by the University of Leeds and focuses on six major groups of metal containing proteins diiron-carboxylate proteins, haem proteins, iron-sulfur proteins, molybdopterin proteins, mononuclear iron proteins, and chlorophyll containing proteins156. ... [Pg.154]

Lui, S.M. and J.A. Cowan (1994). Direct reversible protein electrochemistry at a pyrol54ic graphite electrode. Characterization of the redox thermodynamics of the Fe4S4-siroheme prosthetic center in the hexameric dissimilatory sulfite reductase and the monomeric assimilatory snlflte reductase from desulfovibrio vulgaris (Hilden-hourgh). Systematic pH titration experiments and implications for active site chemistry./.Am. Chem. Soc. 116, 11538-11549. [Pg.183]

The vast majority of enzyme biofuel cells is based on the electroenzymatic oxidation of glucose by glucose oxidase (GOX) and oxygen reduction by laccase, rarely, bilirubin oxidase, or even ascorbate oxidase. Usually two couples of redox mediators are involved in the functioning of the enzymatic biofuel cell. One is required to establish an electrical connection between the electrode surface and the reduced form of flavin adenine dinucleotide, the prosthetic center of GOX. The second couple, located at the cathode, allows the electron transfer from the electrode siuface to the copper center of laccase where the oxygen reduction takes place (Fig. 3.2). [Pg.51]

The prosthetic groups of the R. timdw reaction center (P870, BChl, BPheo, and... [Pg.723]

FIGURE 22.18 Model of the R. viridis reaction center, (a, b) Two views of the ribbon diagram of the reaction center. Mand L subunits appear in purple and blue, respectively. Cytochrome subunit is brown H subunit is green. These proteins provide a scaffold upon which the prosthetic groups of the reaction center are situated for effective photosynthedc electron transfer. Panel (c) shows the spatial relationship between the various prosthetic groups (4 hemes, P870, 2 BChl, 2 BPheo, 2 quinones, and the Fe atom) in the same view as in (b), but with protein chains deleted. [Pg.725]

All the complexes consist of several subunits (Table 2) complex I has a flavin mononucleotide (FMN) prosthetic group and complex II a flavin adenine dinucleotide (FAD) prosthetic group. Complexes I, II, and III contain iron-sulphur (FeS) centers. These centers contain either two, three, or four Fe atoms linked to the sulphydryl groups of peptide cysteine residues and they also contain acid-labile sulphur atoms. Each center can accept or donate reversibly a single electron. [Pg.121]

SSIs are defined and reported according to Centers for Disease Control and Prevention (CDC) criteria.5 SSIs are classified as either incisional or organ/space. Incisional SSIs are further divided into superficial incisional SSI (skin or subcutaneous tissue) and deep incisional SSI (deeper soft tissues of the incision). Organ/space SSIs involve any anatomic site other than the incised areas. For example, a patient who develops meningitis after removal of a brain tumor could be classified as having an organ/space SSI. An infection is considered an SSI if any of the above criteria is met and the infection occurs within 30 days of the operation. If a prosthetic is implanted, the timeline extends out to 1 year. [Pg.1232]

Tatur, J. and Hagen, W.R. 2005. The dinuclear iron-oxo ferroxidase center of Pyrococcus furiosus ferritin is a stable prosthetic group with unexpectedly high reduction potentials. FEBS Letters 579 4729 1732. [Pg.238]

Fig. 1. Space filling model of yeast iso-1-cytochrome c. The edge of the heme prosthetic group is visible as a black linear structure in the center of the protein. Phe-82 is shaded a dark gray at the left upper side of the heme group... Fig. 1. Space filling model of yeast iso-1-cytochrome c. The edge of the heme prosthetic group is visible as a black linear structure in the center of the protein. Phe-82 is shaded a dark gray at the left upper side of the heme group...
Peroxidases (E.C. 1.11.1.7) are ubiquitously found in plants, microorganisms and animals. They are either named after their sources, for example, horseradish peroxidase and lacto- or myeloperoxidase, or akin to their substrates, such as cytochrome c, chloro- or lignin peroxidases. Most of the peroxidases studied so far are heme enzymes with ferric protoporphyrin IX (protoheme) as the prosthetic group (Fig. 1). However, the active centers of some peroxidases also contain selenium (glutathione peroxidase) [7], vanadium (bromoperoxidase)... [Pg.75]

Let us return to the cases of myoglobin and hemoglobin and recognize something explicitly these two proteins contain a nonprotein constiment. This constituent, or prosthetic group, is heme, a complex polycyclic structure, protoporphyrin IX, containing an atom of iron (as Fe (II) or Fe +) at its center. [Pg.145]


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See also in sourсe #XX -- [ Pg.154 ]




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