Prostanoids tafluprost

Fluorinated Prostanoids Development of Tafluprost, a New Anti-glaucoma Agent... 

Since the acid form of tafluprost did not show significant affinities for other prostanoid receptors, the drug proved to be a highly selective compound [35]. Compared with the other prostanoids [26b, 36], tafluprost is regarded as one of the most selective prostanoid FP receptor agonists. 

Source Reprinted from Takagi, Y., Nakajima, /., Shimazaki, A., et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp. Eye Res., (2004) 78, 767-776, with permission from Elsevier)... 

In long-term clinical use, prostanoids are known to cause iris pigmentation as a characteristic side-effect this has been observed in 5-15% of patients treated [27], In cultured melanoma cells, a carboxylic acid of latanoprost has been reported to increase melanogenesis [45], However, a carboxylic acid of tafluprost did not have the stimulatory effects... 

Ota, T., Aihara, M., Saeki, T., et al. (2007) The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice. British Journal of Ophthalmolology 91, 673-676. 

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