Prostaglandins arterial thrombosis

Bourgain RH, Andries R, Braquet P. (1987). Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. Adv Prostaglandin, Thromboxane, Leukotriene Res. 17B 815-17. 

Tada M, Esumi K, Yamageshi M et al. (1984) Reduction of prostaglandin synthesis as a possible cause of transient flow reduction in a partially constricted canine coronary artery. Mol Cell Biol 16 1137-1149 Uchida Y, Yoshimoto N, Murao S (1975) Cyclic fluctuations in coronary blood pressure and flow induced by coronary artery constriction. Jpn Heart J 16 454—464 Warltier DC, Lamping KA, Pelc LR, Gross GJ (1987) A canine model of thrombin-induced coronary artery thrombosis Effects of intracoronary streptokinase on regional myocardial blood flow, contractile function, and infarct size. J Pharmacol Meth 18 305-318... 

Summary - Many diverse novel compounds that inhibit different platelet functions show great promise, not only for potential anti-thrombotic agents, but also for more specific effects on prostaglandin and/or thromboxane A2 synthesis, and serotonin or calcium uptake and release. Many active compounds can be used as tools in the search toward a more complete understanding of the physiologic interactions of the hemostatic mechanisms. This better understanding would lead to the development and use of more potent and selective synthetic compounds in the inhibition of platelet aggregation and fibrin formation, and in the enhancement of fibrinolysis for the control of both arterial and venous thrombosis. It is hoped that some of these new compounds will be evaluated clinically in the near fu ture. 

I he prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase whkh results In the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and Is used In the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30Ch ed, pS)... 

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