Thromboxane A2 synthase

Thromboxane-A2 receptor/thromboxane-A2 synthase (TxA2/TxS) as anti-platelet agents. 

Kajita S, Ruebel KH, Casey MB, Nakamura N, Lloyd RV. Role of COX-2, thromboxane A2 synthase, and prostaglandin 12 synthase in papillary thyroid carcinoma growth. Mod Pathol. 18 (2005) 221-227. 

Ohshima, E., Sato, H., Obase, H., Miki, I., Ishii, A., Kawakage, M., Shirakura, S., Karasawa, A. and Kubo, K. (1993) Dibenzoxepin derivatives Thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule. J. Med. Chem. 36 1613-1618. 

Jacobs, C., Frotscher, M., Dannhardt, G. and Hartmann, R.W. (2000) l-Imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues Syntheses and evaluation of dual inhibitors of thromboxane A2 synthase and aromatase. J. Med. Chem. 43 1841-1851. 

Cozzi, P., Carganico, G., Fusar, D., Grossoni, M., Menichincheri, M., Pinciroli, V., Tonani, R., Vaghi, F. and Salvati, P. (1993) Imidazol-l-yl and pyridin-3-yl derivatives of 4-phenyl-l,4-dihydropyridines combining Ca" " antagonism and thromboxane A2 synthase inhibition. J. Med. Chem. 36 2964-2972. 

Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M (2013) Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers. Gastroenterology 145 658-667, e611... 

Neri Semeri GG, Coccheri S, Marubini E, Violi F (2004) Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease the DAVID study. Eur Heart 125 1845-1852... 

Piadono R Tazawa R, Maemondo M, Tanaka M, Usui K, Saijo Y, Hagiwara K, Nukiwa T (2002) Gene transfer of thromboxane A2 synthase and prostaglandin Ij synthase antithetically altered tumor angiogenesis and tumor growth. Cancer Res 62 63 6... 

Ruan KH, Li P, Kulmacz RJ, Wu KK. Characterization of the structure and membrane interaction of NH2 -terminal domain of thromboxane A2 synthase. J Biol Chem 1994 269 20938-20942. 

Kurosawa M. Role of thromboxane A2 synthase inhibitors in the treatment of patients with bronchial asthma. Clinical Therapeutics 1995 17 2-11. 

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