Prosopis juliflora alkaloids from

Juliprosopine from Prosopis juliflora A. DC. is a new type of indolizidine alkaloid, and on the basis of an extensive spectroscopic and chemical study it has been assigned the structure (2), in which relative configurations are shown for the substituents on the piperidine ring. Juliprosopine may be derived biosynthetically from combination of a dihydropyrrole unit with two Prosopis piperidine alkaloids that have C12 side-chains.2... 

Juliprosopine (318) and juliprosine (319) (Fig. 5), indolizidine alkaloids of the genus Prosopis (mesquite family Leguminosae), had been partially characterized at the time of the previous review on the topic in this serial (7). Rather few advances have been made since then no further stereochemical clarification has been forthcoming, and no further work has been reported on two other putative Prosopis indolizidines, isojuliprosopine and isojuliprosine (295). However, the alkaloid juliflorine, previously isolated from Prosopis juliflora by workers from Pakistan (296,297), has since been shown to be identical to juliprosopine (298). 

Juliprosine, isolated from Prosopis juliflora A.DC., has the structure (1). Reduction of the dihydroindolizinium system gives a hexahydroderivative identical with the product from catalytic hydrogenation of the closely related alkaloid juliprosopine (cf. 

Three new alkaloids have been isolated from the leaves of Prosopis juliflora DC. (mesquite). The minor base, julifloridine, has been examined spectroscopically, and structure (21), of unspecified relative and absolute configuration, has been advanced for it. The other two bases, juliflorine and julifloricine, are also 3-hydroxy-2-methyl-piperidines of apparently more complex structure.Spec-talinine (22) and iso-6-carnavaline (23) are two new piperidine bases occurring in... 

The unusual indolizidine alkaloid julisporine (39) from Prosopis juliflora (Fabaceae) possessed in vitro activity against several dermatophytic fungi (Clark and Hufford, 1992). 

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