2- propylvaleric acid

Valproic acid 2-Propylvaleric acid 2-Propylpentanoic acid di-w-Propylacetic acid Sodium valproate Sodium 2-propylvalerate Sodium 2-propylpentanoate Sodium di-w-propylacetic acid Sodium di-w-propylacetate... 

Valproic acid is 2-propylpentanoic acid. It is also known as n-dipropylacetic acid, 2-propylvaleric acid, DPA, and by many slight variations of the particular nomenclature. 

Valproic acid, 2-propylvaleric acid (9.4.3), is synthesized by the alkylation of cyanoacetic ester with two moles of propylbromide, to give dipropylcyanoacetic ester (9.4.1). Hydrolysis and decarboxylation of the carbethyoxy group gives dipropylacetonitrile (9.4.2), which is hydrolyzed into valproic acid (9.4.3) [12-15]. 

At the borderline between semisynthesis and patterned synthesis, versatile total syntheses may provide access to diversified bioactive structures. Classically, analogues of the active drug are sought that avoid the resistance developed by pathogens and show reduced side effects. In lucky cases, chemical simplification has afforded the wonder drug. This is the case of sodium valproate (2-propylvaleric acid sodium salt), which was synthesized in the fall of the XIX century and nearly a hundred years later became a leading drug in the treatment of epilepsy. 

Valproic acid (= 2-Propylpentanoic acid 2-Propylvaleric acid)] (carboxylic acid) Synthetic GABA transaminase inhibitor (cf. 4-Hydroxybenzaldehyde) [anticonvulsant, antiepileptic]... 

Proprietary Names. Convulex (capsules) Depakene (capsules). 2-Propylvaleric acid C8H,e02= 144.2 CAS—99-66-1... 

Sou, Chem. Abstracts, 1936, 30, 4463. Dipropylacetic Acid (HeptaneA.earboxylic acid, l-propylvaleric acid)... 

Sodium 2-propylvalerate Pentanoic acid, 2-propyl-, sodium salt Valproic acid U.S.P.,... 

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