Propylamine as reagent

Triple bonds s. Acetylene derivs. Triplet sensitizer -, anthraquinone as - 26,990 Tri-n-propylamine as reagent 26, 66, 564... 

Relative rates of alkylation of toluene and benzene using a mixture of nitro-sonium hexafluorophosphate, nitromethane (or acetonitrile) and aliphatic amine as the alkylations agent have been determined at 25 °C as follows360 1.5 (ethyl-amine), 2.5 (i-propylamine) and 3.5 (benzylamine) nothing more as yet is known about the kinetics of alkylation with these new alkylating reagents. 

Fig. 18 Chiral selectivity (ko/kL) as a function of the number of non-hydrogen atoms on the amino acid. Hosts permethylated j8-CD reagent base 1-propylamine. Chiral selectivity tends to increase with the size of the amino acids. Phe and Tyr, however, do not follow this trend.

On the basis of the above experimental facts, enaminones 42 are considered to be usable as the dinucleophilic reagents for the RTF reaction leading to 4-aminopyridine-3-carboxylic acid derivatives 41 (Table 11) [60]. Enaminones 42 are readily prepared by only mixing 1,3-dicarbonyl compounds 19 and amines without solvent. When enaminone 42i derived from ethyl ace-toacetate 19a and propylamine is used, the RTF reaction proceeds to afford ethyl AT-propyl-4-aminopyridine-3-carboxylate 41i in 88% yield. The amino group of 41 is easily modified by changing amine, and pyridine-3-carboxylic... 

In the meantime, the primary amines from the chiral pool (Sect. 4.3.1.3) and other amines have been tested for their induction ability, and found to give similar results as l-ferrocenyl-2-methyl-propylamine [40, 75, 76]. Although there has been some optimism towards a broader range of applications [164], it seems that carbohydrate-derived primary amines have a superior induction power in stereoselective 4CC and will therefore become the reagents for the future. 

Kinetic resolution of secondary allylic alcohols by Sharpless asymmetric epoxidation using fert-butylhydroperoxide in the presence of a chiral titanium-tartrate catalyst has been widely used in the synthesis of chiral natural products. As an extension of this synthetic procedure, the kinetic resolution of a-(2-furfuryl)alkylamides with a modified Sharpless reagent has been used . Thus treatment of racemic A-p-toluenesulphonyl-a-(2-furfuryl)ethylamine [( )-74] with fert-butylhydroperoxide, titanium isopropoxide [Ti(OPr-/)4], calcium hydride (CaHa), silica gel and L-(+)-diisopropyl tartrate [l-(+)-DIPT] gave (S)-Al-p-toluenesulphonyl-a-(2-furfuryl)ethylamine [(S)-74] in high chemical yield and enantiomeric excess . Similarly prepared were the (S)-Al-p-toluenesulphonyl-a-(2-furfuryl)-n-propylamine and other homologues of (S)-74 using l-(+)-D1PT. When D-(—)-DIPT was used, the enantiomers were formed . ... 

Another combination of reagents, in which 3-cyclohexylaminopyrimido-pyridazine 47g is used as substrate and propylamine or butylamine as nucleophile, affords imidazolines 56a,b, isomeric to compounds 49c,d. Apparently, the process starts with oxidation of 3-alkylamino group of the starting aromatic substrate and proceeds as shown in Scheme 33. 

Amine etching was used to reveal the structure of PET as early as 1959 [55] when PET fibers were etched with n-propylamine for replica formation. Methylamine was also used [248], although the selectivity of the reagent was questioned. Tucker and Murray [249] etched PET filaments with 42% aqueous solutions of n-propylamine at 30°C. Apparently, the first step in the reaction is the removal of the fiber skin and then crazing. A... 

FIGURE 7.18 (a) PICI spectrum of V-nitroso-di-n-propylamine (peak 4 in Figure 7.17a) with ammonia as the reagent gas. (b) PICI spectrum of V-nitroso-di-n-propy-lamine (peak 4 in Figure 7.17b) with isobutane as the reagent gas. (c) PICI spectrum of V-nitroso-di-n-propylamine (peak 4 in Figure 7.17c) with methane as the reagent gas. (Masucci and Caldwell, unpublished data.)... 

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