Propranolol buccal absorption

Coutel-Egros A, Maitani Y, Veillard M, Machida Y, Nagai T (1992) Combined effects of pH, cosolvent and penetration enhancers on the in vitro buccal absorption of propranolol through excised hamster cheek pouch. Int J Pharm 84 117-128... 

Henry JA, Ohashi K, Wadsworth J, Turner P (1980) Drug recovery following buccal absorption of propranolol. Br J Clin Pharmacol 10 61-65... 

Schumann W, Turner P (1978) Membrane model of the human oral mucosa as derived from buccal absorption performance and physicochemical properties of the beta-blocking drugs atenolol and propranolol. J Pham Pharmacol 30 137-147... 

Schumann W, and Turner P (1977) The buccal absorption of atenolol and propranolol, and their physicochemical characteristics. Br. J. Clin. Pharmacol. 4 655P-656P. 

Buccal Absorption at Various pH s. I would like to show you one additional example that supports the premise that log D correlations relate to the amount of a compound at a site, that I find very impressive. Not only can one combine data for the absorption of acids and bases, but the regression results hold for any pH (any pH not affecting the system itself). Schurman and Turner (8) measured the buccal absorption rate of propranolol and n-hexylphenylacetic acid from pH 4 to pH 9. (Table IV). The absorption rate for these compounds is well described by the simple equation 9. A quadratic equation (10) provides an even better fit. 

Eq. Ill [345] correlates the buccal absorption rate constants of an acid (p-hexylphenylacetic acid, pK = 4.36) and a base (propranolol, pK = 9.45) at different pH values with log Papp values (Table 16) [345, 470]. 

Table 16. Buccal absorption of propranolol and p-hexylphenylacetic acid at dilTerenl pH values [345,470]...

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