Salicylates propoxyphene

The following are examples of substances that may increase the blood glucose-lowering effect and susceptibility to hypoglycemia oral antidiabetic products, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates, and sulfonamide antibiotics. 

I. M. Jalal and S. I. Sa sa, Simultaneous determination of dextro-propoxyphene napsylate, caffeine, aspirin and salicylic acid in pharmaceutical preparations by reversed-phase HPLC, Talanta, 37 1015 (1984). 

The salicylates are beneficial for pain associated with inflammation, but their use has now been generally supplanted by other NSAIDs, largely because of gastrointestinal (GI) distress. Nevertheless, the salicylates are effective for treatment of mild to moderate pain and may produce analgesic effects comparable with those of weak narcotics such as propoxyphene hydrochloride. When used in combination with narcotics, the salicylates can be effective for severe pain accompanying acute ocular trauma or inflammation. 

Although thromboprophylaxis of microvascular anastomoses seems advisable theoretically, there is little clinical evidence to support the use of dextran for this purpose. The pulmonary edema in these cases was thought to be non-cardiogenic, similar to that caused by heroin, methadone, propoxyphene, and salicylates, due to a direct adverse effect on the pulmonary vasculature, rather than anaphylaxis, cardiac pump failure, or volume overload. 

Furazolidone Metronidazole Minocycline Paromomycin Polymyxin B Salicylates and NSAIDs Loop diuretics Antitumor agents Miscellaneous Morphine Penicillamine Pentazocine Propranolol Propoxyphene... 

Extracted allobarbital, azinphos, barbital, brallobarbitone, bromazepam, butethal, caffeine, carbamazepine, ceirbaryl, cephaloridine, chloramphenicol, cblordiazepoxide, chlorothiazide, chlorvinphos, clothiapine, cocaine, coomassie blue, desipramine, diazepam, diphenhydramine, dipipanone, ethylbromphos, flufenamic acid, formothion, griseofiilvin, indomethacin, lidocaine, lorazepam, malatbion, medazepam, midazolam, oxazepam, par-aoxon, penicillin G, pentobarbital, prazepam, propoxyphene, prothiophos, quinine, salicylic acid, secobarbital, strychnine, sulfamethoxazole, theophylline, thiopental, thioridazine, trimethoprim... 

Lurie, I.S. McGuiness, K. The quantitation of heroin and selected basic impur-ties via reversed phase HPLC. II. The analysis of adulterated samples. J.Liq.Chromatogr., 1987, 10, 2189—2204 [also impurities, acetaminophen, acetylcodeine, acetylmorphine, acetylprocaine, aminopyrene, amitriptyline, antipyrene, aspirin, barbital, benztropine, caffeine, cocaine, codeine, diamorphine, diazepam, diphenhydramine, dipyrone, ephedrine, ethylmorphine, lidocaine, meconin, methamphetamine, meth-ap Tilene, methaqualone, monoacetylmorphine, morphine, nalorphine, niacinamide, nicotinamide, noscapine, papaverine, phenacetin, phenmetrazine, phenobarbital, phenolphthalein, procaine, pro-panophenone, propoxyphene, P5rilamine, quinidine, quinine, salic lamide, saUsalicylic acid, secobarbital, strychnine, tetracaine, thebaine, tripelennamine, tropacocaine, vitamin B3, vitamin B5 electrochemical detection]... 

Wilson, T.D. Recent advances in HPLC analysis of analgesics. J.Liq.Chromatogr., 1986, 9, 2309-2410 [also antipyrine, aspirin, buprenorphine, butorphanol, codeine, cyclazocine, diamorphine, dihydrocodeine, etorphine, fentanyl, heroin, hydrocodone, hydromorphone, ibuprofen, LAAM, levorphanol, meperidine, methadone, morphine, nalbuphine, naproxen, oxycodone, ox nnorphone, pentazocine, phenacetin, phenazocine, phenylbutazone, propoxyphene, salicylamide, salicylic acid, zomepirac]... 

Noninterfering acetaminophen, allopurinol, amikacin, amoxapine, amytal, bretylium, caffeine, carbamazepine, carisoprodol, chloramphenicol, chlordiazepoxide, chlorpropamide, clonazepam, codeine, diazepeun, disop30 amide, droperidol, ethinamate, ethinamate, etho-suximide, fluphenazine, flurazepam, furosemide, gentamicin, haloperidol, hydrochlorothiazide, hydro yzine, ibuprofen, kanamycin, lidocaine, loxapine, meperidine, mepho-barbital, meprobamate, methaqualone, methotrexate, morphine, nafcUlin, naloxone, neomycin, perphenazine, phenacetin, phenobarbital, phenytoin, prazepam, primidone, procaine, propoxyphene, reserpine, salicylamide, salicylic acid, secobarbital, spironolactone, theophyUine, thiopental, thioridazine, tobramycin, valproic acid, verapeunil... 

The administration of CNS depressants as a result of failure to recognize salicylate intoxication may be disastrous (21 -). A case of combined overdosage with aspirin and d-propoxyphene with a fatal outcome has been reported (26 -). 

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