Propiophenones hydroxy

The initial steps involve reacting benzyl chloride with 4-hydroxy propiophenone. The benzyl-oxypropiophene thus obtained is first brominated and then reacted with 4-benzylpiperidine to give 1-(p-benzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one. 

Hydroxy-propiophenon 2 -Hydroxy-chalcon 5-Chlor-2-hydroxy-benzophenon 2-Hydroxy-1 -formyl-naphthalin... 

Hydroxy-propiophenon wird in 10%-iger Natronlauge an Zinn-beschichteter Kup-fer-Kathode zu 3,4-Bis- 4-hydroxy-phenyl]-hexandiol-(3,4) (96% d.Th.) dimerisiert8 ... 

Photoinitiator Studies. A study with the UPE A/DVE-3 formulation using 2-hydroxy-2-methyl propiophenone as the photoinitiator showed that there was no difference in MEKDR values when the level of photoinitiator was varied from 0.5 to 3.0% even when dosages as low as 0.3 J/cm2 were used. Thus, a photoinitiator level of 3.0% was chosen to evaluate some common photoinitiators using the UPE A system. The results are shown in Table V. 

Photoinitiators 2-hydroxy-2-methyl propiophenone and diphenyl-(2,4,6-trimethylbenzoyl) phosphine oxide both gave at least 100 MEKDR with no damage to the film surface when cured at a dosage as low as 0.5 J/cm2. This preference in photoinitiators has been observed in other studies of the maleate/vinyl ether system.1011... 

A good correlation was obtained in 20-80% acetonitrile-water mixtures. The standard non-ionic compounds used to evaluate the columns were 2-hydroxy-acetophenone, coumarin, acetophenone, indole, propiophenone, butyro-phenone, isopropyl benzoate, butyl benzoate, and isopentyl benzoate. The plotted lines for the linear relationship measured in five different proportions... 

C,3H,9N03 2-Hydroxy-4-n-butoxy-propiophenone oxime Spectrophotometric Fe 44... 

Proline, hydroxy Lf L Ff Propionamide, N-ethyl Lf Propiophenone, 2-4-dimethyl Lf Propiophenone, para-ethyl Lf ... 

Growth conditions in deep-well microtiter plates were optimized with respect to optimal expression of active enzymes (Fig. 2.2.1.1). The best results were obtained with an expression time of 20 h at 37 °C (Fig. 2.2.1.1, lanes 7-9). Subsequently, E. coli cells were enzymatically disrupted by lysozyme treatment, and the carboligase activity was monitored by a modified tetrazolium salt color assay [16], This color assay is based on the reduction of the 2,3,5-triphenyltetrazolium chloride (TTC) 13 to the corresponding formazan 15, which has an intense red color (Fig. 2.2.1.2A). Before screening ofa BFD variant library, substrates and products were tested in the color assay. Neither substrate, benzaldehyde 4 nor dimethoxy-acetaldehyde 8, reduced TTC 13 however, the product 2-hydroxy-3,3-dimethoxy-propiophenone 10 already caused color formation at low concentrations of 2.5-10 mM (Fig. 2.2.1.2B). Benzoin 12 as the product also gave a color change at a similar concentration (data not shown). 

With respect to the carboligase activity, PDCI472A proved to be a real chimera between PDC and BFD, while BVDA460I/F464I provided the most interesting result with an almost complete reversal of the stereochemistry of its 2-hydroxy-propiophenone product [7, 9]. 

Anionic oxy-Claisen rearrangement.2 The [3,3] Claisen rearrangement of en-olates of a-allyloxy ketones is markedly dependent on the nature of the metal hydride used, and to a less extent, the solvent. An example is the rearrangement of a-(allyloxy)propiophenone (1) to the a-hydroxy ketone 2. The rearrangement... 

Experimental procedures are given in Expt 6.107 for o- and p-hydroxy-propiophenones (R = Et). The ortho-para ratio in the product is influenced by the nature of the alkyl residue, the temperature, the solvent and the amount of aluminium chloride used generally low temperatures favour the formation of p-hydroxyketones. It is usually possible to separate the two hydroxyketones by fractional distillation under reduced pressure through an efficient fractionating column or by steam distillation the ortho isomers, being chelated, are more steam volatile. It may be mentioned that Clemmensen reduction (cf. Sections 5.1.3, p. 476 and 6.1.1, p. 826) of the hydroxyketones affords an excellent route to alkyl phenols. 

Using other hypervalent iodine compounds or different reagent combinations, various functional groups can be introduced in the a-position of ketones. a-Tosylations of ketones can be achieved directly using [hydroxy(tosyloxy)-iodo]benzene 6. The major drawback is the low regioselectivity observed in these reactions, although the a-tosylation of silyl enol ethers circumvents this problem. In the last few years some efforts have been done in the synthesis of chiral hypervalent iodine compounds [48, 53-55,113-117], but only a few of them have been used successfully in stereoselective synthesis. With chiral derivatives of type 59 it is possible to a-tosylate propiophenone with about 40% ee [56,118,119]. 

The resulting residue, which consisted of the hydrochloride of 4 -hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propiophenone, was mixed with 30 ml of a 48% hydrobromic acid solution and the mixture was boiled until no methylbromide developed any more, which was the case after approximately... 

Kindler et al. hydrogenated a-hydroxyiminoacetophenone and a-hydroxyimino-propiophenone (eq. 8.26) to the corresponding phenylalkylamines over a palladium black in acetic acid in the presence of sulfuric acid.51 The hydrogenolysis of the intermediate amino alcohols proceeded not at all in alcohol and acetic acid, and only rather slowly in acetic acid-sulfuric acid. In contrast, 3 -hydroxy-3 -phenylpropylamine, with one more carbon atom between the hydroxyl and amino groups, was hydrogenolyzed much faster under these conditions. Perchloric acid may also be used instead of sulfuric acid, but some hydrogenation of the aromatic ring occurred even when the hydro-... 

Aqueous solutions Complexation with o-hydroxy-propiophenone isonicotinoyl-hydrazone Spectro- photometric No data No data Ramachandraiah et al. 1993... 

It is well-established [74] that the low-molecular-weight structural model 2-hydroxy-2-methyl propiophenone (HIPK), upon irradiation, undergoes a-clea-vage which is the main decay of the triplet state. Moreover, the absence of any aromatic substituent in the hydroxyalkyl moiety prevents the formation of yellow compounds with semiquinoid structures as those obtained [91,92] in the case of DMPA (Scheme 20), thus allowing one to achieve uncoloured clear coatings. 

HIPK 2-hydroxy-2-methyl propiophenone. ITX 2-isopropyl thioxanthone... 

At higher pH-values the second reduction wave of phenyl vinyl ketone becomes smaller than the first. Hence the decrease in height of the first wave in the course of the reaction with hydroxyl ions is accompanied by an increase of the second wave (Fig. 14). The low second wave of phenyl vinyl ketone is replaced by the two-electron wave of )3-hydroxy-propiophenone. 

The reaction was practically irreversible. Attempts to isolate j8-hydroxy-propiophenone or to prepare it by an independent route failed. The formation of /S-hydroxypropiophenone was postulated from the kinetics observed, proved by the IR-spectra and supported by the analogy with the reaction of chalcone in which case the ketol was isolated. 

Hydroxy-benzophenones and -propiophenones can be obtained in the same way substituted salicylic acid ethers and phenols lead to xanthones by way... 

Treatment of the cyclic ethylene acetal la in chlorobenzene at 403 K in the presence of the eight ion exchanged zeolites affords variable mixtures of 2-bromopropiophenone (2), 2-hydroxyethyl 2-phenylpropanoate (3a) and 5-methyl-6-phenyl-2,3-dihydro-1,4-dioxin (4a). Trace amounts of propiophenone, 2-hydroxypropiophenone, 1 -hydroxy-1 -phenylpropanone and 2-phenylpropanoic acid were also present in some reaction mixtures. 

Sodium phenoxide and chloroacetone reacts to give a mole of phenoxyacetone with the elimination of a mole of NaCl, which on reductive amination in the presence of ammonia and hydrogen yields an amine. This amine on treatment with -hydroxy-propiophenone gives an intermediate that on further treatment with sodium borohydride yields isoxupurine which when treated with hydrochloric acid affords the official compound. 

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