Propionaldehyde 2.3- dibromo

Synonyms Acrolein dibromide Dibromopropanal Dibromopropionaldehyde Propanal, 2,3-dibromo- Propionaldehyde, 2,3-dibromo-... 

Propionaldehyde, p-(4-t-butylphenyl)-a-methyl-. See 4-t-Butyl-a-methylhydrocinnamaldehyde Propionaldehyde, 2,3-dibromo-. See 2,3-Dibromopropionaldehyde Propionaldehyde, 2-methyl-2-(methylthio)-, O-(methylcarbamoyl) oxime. SeeAldicarb Propionaldehyde, 2-methyl-2-(methylthio)-, oxime. See Aldicarb oxime Propionaldehyde, 3-(methylthio)-. See3-Methylthiopropionaldehyde Propionamide, N,N-diethyl-2-(1-naphthyloxy)-. See Napropamide Propione. See Diethyl ketone Propionic acid... 

Propionaldehyde was brominated by bromine and the propanoilbromide was obtained. Then propanoilbromide reacted with methanol and hydrobromic acid yielding 1,2-dibromo-l-methoxypropane. 

Studies in this area were reported as early as 1949 by Lederle chemists [243], who used the Waller synthesis (2,4,5,6-tetraaminopyrimidine, 2,3-dibromo-propionaldehyde and an Af-(4-aminobenzoyl)-a-amino acid or ester) to prepare the alanine, valine, isoleucine, serine, threonine, phenylalanine and tryptophan analogues (VIII.1)-(VIII.7), respectively. Compounds (VIII.2) and (VIII.3) were also treated with CI2 in AcOH to obtain the 3 -chloro derivatives (VIII,8) and (VIII.9). Although the data reported were very scanty, consisting only of activity ratios relative to 10-methylfolic acid in the S.faecium microbioassay, replacement of the glutamate moiety by a-amino monoacids was clearly shown to be an unpromising route to potent antifolates. 

In the above method of synthesis of fohc acid and its derivatives, any of a variety of three carbon compounds can be used to replace the dibromo-propionaldehyde. In general, these include di- or tri-halo or haloketo derivatives of propionaldehyde or acetone , or similar negatively substituted derivatives. In several cases the addition of sulfite appears to be beneficial. ... 

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