Propargylic acid esters

Steric effects and FMO control have been combined in an elegant way to achieve regiospecific synthesis of pyrazole inhibitors of dihydroorotate dehydrogenase <2006SL901>. When the size of the propargylic acid ester 86 is increased from ethyl to diphenylmethyl, pyrazole 87 is formed from compound 85 regiospecifically (Scheme 3 Table 4) <2006H(68)1007>. 

Under the same conditions even free alkynyl aldehydes undergo a 1,4-addition to propargylic acid esters (eq. (6)) [14]. 

Takasu, Ihara and coworkers described an efficient synthesis of ( )-paesslerin A (4-73) using a combination of a [4+2] and a [2+2] cycloaddition (Scheme 4.16) [25], Reaction of 4-71 and propargylic acid methyl ester in the presence of the Lewis acid EtAlCl2 led to 4-72 in 92 % yield, which was converted in six steps into the desired natural product 4-73 by transformation of one of the ester moieties into a methyl group, hydrogenation of one double bond, removal of the other ester moiety, and exchange of the TIPS group for an acetate. 

In a similar manner, 2,4,6-trisubstituted 3-pyridinecarboxylic acid esters have been prepared using a mixture of a, 3-ketoesters, propargylic alcohols, ammonium acetate and Mn02. The reaction proceeds by oxidation of the propargylic alcohol to the corresponding ketone, which reacts with the enamine being formed from the like loos lor and ammonium acetate. For this domino process, normal heating at 70 °C was used. 

The first syntheses of a-allenic a-amino acids [131,133] took advantage of Steg-lich s [134] protocol for the oxazole-Claisen rearrangement of unsaturated N-ben-zoylamino acid esters (Scheme 18.46). Thus, treatment of the propargylic ester 143 with triphenylphosphine and tetrachlormethane furnished the allenic oxazolone 144, which was converted into the amino acid derivative 145 by methanolysis. Stepwise deprotection finally led to the allenic DOPA analog 146, which shows a much higher decarboxylase-inhibiting activity than a-vinyl- and a-ethynyl-DOPA [133],... 

The boronic acid ester B was synthesized by transesterification of the corresponding pinacolester A with (lR,2R)-l,2-dicyclohexyl-l,2-dihydroxyethane. Stereoselective chlorination of B was carried out with (dichloromethyl) lithium and zinc chloride. Reaction of the obtained chloroboronic ester C with lithio 1-decyne followed by oxidation of the intermediate D with alkaline hydrogen peroxide afforded the propargylic alcohol E. Treatment with acid to saponify the tert-butyl ester moiety and to achieve ring closure, produced lactone F. Finally, Lindlar-hydrogenation provided japonilure 70 in an excellent yield and high enantiomeric purity. 

In a similar way, propargyl esters of A -benzoyl-a-amino acids have been converted into a-allenyl-a-amino acid esters 113 by cyclization to oxazoles 111 followed by Claisen rearrangement to the 4-allenyl-2-phenyl-5(4//)-oxazolones 112. Oxazolone ring opening with methanol then afforded 113 (Scheme 7.32). ... 

Rh complexes are examples of the most effective catalysts for the polymerization of monosubstituted acetylenes, whose mechanism is proposed as insertion type. Since Rh catalysts and their active species for polymerization have tolerance toward polar functional groups, they can widely be applied to the polymerization of both non-polar and polar monomers such as phenylacetylenes, propiolic acid esters, A-propargyl amides, and other acetylenic compounds involving amino, hydroxy, azo, radical groups (see Table 3). It should be noted that, in the case of phenylacetylene as monomer, Rh catalysts generally achieve quantitative yield of the polymer and almost perfect stereoregularity of the polymer main chain (m-transoidal). Some of Rh catalysts can achieve living polymerization of certain acetylenic monomers. The only one defect of Rh catalysts is that they are usually inapplicable to the polymerization of disubstituted acetylenes. Only one exception has been reported which is described below. 

Allenylboronic acid, readily accessible from propargylic halides, on esterification with tartaric acid esters can also be induced to add to aldehydes with high enantioselectivity to give homopropargylic alcohols (Scheme 82). ... 

Menthadien-8-ol (558) has been reported as a new natural product from olibanum resin. This compound had already been synthesized in a routine manner by Hoppmann and Weyerstahl in 1974, from the methyl ester of 4-methyl-1,4-cyclohexadienecarboxylic acid (from isoprene and propargylic acid). ... 

An original, and versatile route toward ulosonic acids has been recently elaborated by Wu et al. [103,104,105], It based on a simple introduction of a-keto acid moiety via propargylation of suitable monosaccharides derived aldehydes and subsequent oxidation of the terminal alkynes. As it is exemplified by preparation of KDO, coupling of 61 with 3-bromopropyne gave the a fr-adduct 139 (Scheme 30). Its bromination using NBS/AgNC>3 provided the bromoalkyne 140, which on reaction with KMnC>4 afforded the desired a-keto acid ester, easily convertible into the anomeric mixture of KDO derivatives 143. The yield of all intermediates were very high. 

A very similar strategy was adopted recently by Pham and co-workers [52] when propargylic fatty ester (PFE) and propargylic fatty diester (PFD) derived from propargyl alcohol and a derivative of oleic acid were converted into lipidic polyols (OHl) and (OFf2), respectively, via thiol-ene and thiol-yne reactions with mercaptoethanol (Scheme 6.19). 

Among other reactions, the bis-metallated species (151) derived from nitroalkanes condense with dialkyl carbonates to give comp>ounds (152), in 60—80% yield, which can serve as precursors of both a-amino-acids and a-hydroxyamino-esters as well as a-keto-esters. Oxazolin-5-ones (153) can be alkylated at the 4-position by alkyl halides in hot DMF containing HMPA and ethyldi-isopropylamine. Yields are good (60—90%) for allylic, benzylic, and propargylic halides but otherwise poor (e.g. 32% with EtI) under these conditions acid hydrolysis of the products affords substituted a-amino-acids. Mesoionic l,3-oxazol-5-ones (154), obtained from imidoyl chlorides and acyl-tetracarbonylferrates, react with alcohols to give N-acyl-a-amino-acid esters. ... 

A review of the rearrangement reaction of anthranilic acid esters, thioesters, or amides under acidic conditions to 2-aryl-3-substituted 4(l//)-quinolinone has been reported and summarizes limits and scope of the reaction in the synthesis of flavonoids. " Theoretical studies of the addition-cyclization-isomerization reaction of propargyl cyanamides with thiol and methanol have been reported to occur via five steps ... 

Trialkynylboranes react with ethyl diazoacetate to give high yields of the corresponding propargylic esters hydration of such esters proceeds uni-directionally, via intramolecular participation of the ester carbonyl group, to give y-keto-acid esters (Scheme 31). 

PdCl2 Propargyl alcohol, propiolic acid, propiolic acid ester ( 90%) 132,133... 

PPh3)2PdCl2 Propiolic acid ester ( 80%), propargyl alcohol 133... 

---