1-Phenyl-1,2-propanedione

D.91) 1,2-Propanedione, 1-phenyl-, 1-phenylpropane-l,2-dione, methyl phenyl diketone, benzoyl methyl ketone, acetylbenzoyl [579-07-7] FEMA 3226... 

Synonyms Acetyl benzoyl Benzoylacetyl Benzoyl methyl ketone Methyl phenyl diketone Methylphenylglyoxal Phenylmethyidiketone 3-Phenyl-2,3-propanedione 1,2-Propanedione, 1-phenyl- Pyruvophenone Empirical C9H8O2... 

Phenylpropanal 1-Phenyl-1,2-propanedione 1-Phenyl-1-propanol 2-Phenyl propanol-1 2-Phenylpropionaldehyde dimethylacetal... 

Another kind of dual activity was given to type I MAI by incorporating hydroxy-phenyl-propanedione-dioxime (HPO) group alternatively with ordinary azo group [Eq. (5)] [11]. 

CD] lxlO 3 M [substrate] 1 M room temperature, spectra measured after 30 min, d-doublet, s-singlet l-Phenyl-l,2-propanedione. 

Recently, it has been shown that ultrasonic agitation during hydrogenation reactions over skeletal nickel can slow catalyst deactivation [122-124], Furthermore, ultrasonic waves can also significantly increase the reaction rate and selectivity of these reactions [123,124], Cavitations form in the liquid reaction medium because of the ultrasonic agitation, and subsequently collapse with intense localized temperature and pressure. It is these extreme conditions that affect the chemical reactions. Various reactions have been tested over skeletal catalysts, including xylose to xylitol, citral to citronellal and citronellol, cinnamaldehyde to benzenepropanol, and the enantioselective hydrogenation of 1-phenyl-1,2-propanedione. Ultrasound supported catalysis has been known for some time and is not peculiar to skeletal catalysts [125] however, research with skeletal catalysts is relatively recent and an active area. 

The plasma half-life of cathinone is 1.5 hours. The primary metabolites are norpseudoephedrine, norephedrine, 3,6-dimethyl-2,5-diphenyl-pyrazine, and l-phenyl-l,2-propanedione (Szendrei 1980 Brenneisen etal. 1986 Guantai and Maitai 1983). However, norpseudoephedrine and norephedrine also originate directly from the leaves, as well as being metabolic products (Widler et al. 1994). Maximal plasma concentrations of norephedrine and norpseudoephedrine are reached at about 3.3 and 3.1 hours, respectively. These two drugs have a much longer duration of action than cathinone, where terminal half-lives could not be calculated after 10 hours. 

C9H10N4OS 1-Phenyl-1,2-propanedione-2-oxime thiosemicarbazone SpecQ-ophotometric Cu, Ni 31... 

CioHi2N4UJ5 1-Phenyl-l, 2-propanedione-2-oxime thiosemicarbazone Spectrophotometric Ni 33... 

Chemical Name 1,3-Propanedione, l-(4-(l,l-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-... 

Recently, a series of studies of the stereoselective reduction of 1,3-diketones has been reported which expands upon this methodology. When 1,3-diphenyl-1,3-propanedione was reduced with three equivalents of NaBH4 in the presence of (S,S)-15,THFA,and ethanol in CHCI3 at -20°C, (S,S)- 1,3-diphenyl- 1,3-propanediol was obtained quantitatively in 97% ee (Scheme 9) [54], The anti syn ratio of the product was 84 16. Diketones with electron-donating and electron-withdrawing substituents on their phenyl rings were also reduced with high enanti-oselectivity and diastereoselectivity. 

Benzoxazines are commonly prepared from 2-aminophenols by reaction with 1,2-dielectrophiles . For example, the aminophenol 344 reacts with -ketoesters to give 345 (Scheme 187) <1961CB1664>, which is probably the result of initial rapid imine formation followed by lactonization. The reaction of 346 and l-phenyl-1,2-propanedione affords a mixture of the isomeric compounds 347 and 348 in a 3 2 ratio (Scheme 188) <1999M1481>. 

Diaminomaleonitrile (178) and l-phenyl-6-(triisopropylsilyl)-hexa-l,5-diyne-3,4-dione (PhC=CCOCOC=CSiPr 3) gave 5- phenylethynyl-6-(triisopropylsilyl)ethynyl-2,3-pyrazinedicarbonitrile (177) (AcOH, 20°C, 5 min 72%)403 the same diamine (178) and 3,3,3-trifluoro-1 -/Molyl-1,2-propanedione (F3CCOCOC6H4Me-p) gave 5-p-tolyl-6-trifluoromethyl-2, 3-pyrazinedicarbonitrile (179) (no details 74%) 807 and the same diamine (178) with / ,//-bis(bromomethyl)benzil (p-BrH2CC6H4COCOC6H4CH2Br-p) gave 5,6-bis[p-(bromomethyl)phenyl]-2,3-pyrazinedicarbonitrile (180)... 

This explanation was shown to be incorrect by investigation 95) of reactions of a number of a-diketones (benzil, biacetyl, 1-phenyl-1,2-propanedione) in the presence of olefins in oxygen saturated solutions. Slow consumption of diketone was observed with relatively rapid consumption of olefin and concomitant formation of epoxides, often in high yield. Many of the olefins which underwent this reaction do not form epoxides at all with singlet oxygen. For example, tetraphenylporphin-sensitized photooxygenation of tetramethylethylene afforded hydroperoxide 111 quantitatively while a biacetyl-sensitized reaction yielded the epoxide 112. Further, it was shown that the... 

Having obtained and described a suitable sample, the next stage is to analyse the material for the presence of cathinone and cathine. In addition to these drugs, other structurally similar compounds found in the C. edulis plant include norephedrine (3). It is well accepted that cathinone is converted into this compound by the process of enzymatic reduction. Furthermore, the oxidation product, 1-phenyl-1,2-propanedione (4), and the cathinone dimer, 3,6-dimethyl-2,5-diphenylpyrazine (5), may also be identified. These, however, are reported to form as artefacts of the isolation and analytical processes [6]. 

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