3- propanamides synthesi

Scheme 7.10 Proposed mechanism for ruthenium-catalyzed 3-(1H-indol-1-yl)propanamide synthesis from phenylpyrazolidin-3-ones.

Synthesis of N-phenyl-N- 1-[2-(4-isothiocyanatophenyl-3,5-3H2)-ethyi]-4-piperidininyl propanamide (125) and 2-(4-ethoxybenzyl)- 1-diethylaminoethyl-5-isothiocyanatobenzimidazole-4,6-3H2 (126)... 

Derivatization of the C-Terminus The derivatization of glycopeptides has been performed with various amines to yield the corresponding amides. An early example is the synthesis of vancomycin propanamide, histamide, and 3-aminopropana-mide with DCC/HOBt. " Solution and solid-phase synthesis protocols were developed to yield similar derivatives as mentioned above, but also C-terminally elongated nonapeptide and decapeptide derivatives have been obtained. The glycopeptide eremomycin was C-terminally converted to the methylester, the hydra-zide, some urea derivatives, and the amide along with the methylamide and the benzylamide. The latter two derivatives were more active than eremomycin. 

An interesting example of template synthesis is the amidomethylation of 2-(hydroxyimino) propanamide in its Niir complex, which gave the carboxamide chelate [Ni(39)] (Equation (2)).50 This is the first example of a ring-closure reaction featuring coordinated amide groups. 

E. Siddalingamurthy, K. M. Mahadevan, T. O. S. Kumar, Synth. Commun. 2013, 43, 3153—3162. Choline chloride/ urea ionic liquid eatalyzed a eonvenient one-pot synthesis of indole-3-propanamide derivatives. 

Bazan reported on the synthesis of pseudo-tetrablock copolymers comprised of ethene and 5-norbomen-2-yl acetate, using the initiator system (LiPr2)Ni(q -CH2Ph) (PMes) [(LiPr2) = 77-(2,6-diisopropylphenyl)-2-(2,6-diisopropylphenylimino) propanamide] and 2.5 equivalents of Ni(cod)2 [bis(l,5-cyclooctadiene)nickel [121, 130, 131]. Square-planar nickel complexes with anionic P,0-chelate ligands were used by Goodall and coworkers for the co- and terpolymerization of norbomene and 5-norbomene-2-carboxylic acid ethyl ester with ethene [126]. 

NaH-dispersion added carefully to a soln. of 2-(benzo[b]thien-4-yloxy)-2-methyl-propanamide in dry hexamethylphosphoramide, and heated 1 hr. on a steam bath N-benzo[b]thien-4-yl-2-hydroxy-2-methylpropanamide. Y 72%. - This is a stage of a 4-step sequence for the prepn. of ar. amines from phenols. F. e. s. R. Bayles et al., Synthesis 1977, 33, 31. 

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