3- propanamides amines

Answer Xl-f is secondary aromatic amide also containing a tertiary aromatic amine function [N-(3-N, N -d mietUy aniino-. phcnyi)propanamide]. 

Derivatization of the C-Terminus The derivatization of glycopeptides has been performed with various amines to yield the corresponding amides. An early example is the synthesis of vancomycin propanamide, histamide, and 3-aminopropana-mide with DCC/HOBt. " Solution and solid-phase synthesis protocols were developed to yield similar derivatives as mentioned above, but also C-terminally elongated nonapeptide and decapeptide derivatives have been obtained. The glycopeptide eremomycin was C-terminally converted to the methylester, the hydra-zide, some urea derivatives, and the amide along with the methylamide and the benzylamide. The latter two derivatives were more active than eremomycin. 

Common functional groups that contain nitrogen atoms are also distinguishable by their IR absorptions above 1500 cm , as illustrated by the IR spectra of an amine (octylarnine), an amide (propanamide), and a nitrile (octanenitrile). Additional details on the IR spectra of these compounds are given in Chapters 22 and 25. 

The X-ray crystal structure has been determined for 2-isopropylamino-5-phenyl-6-methyl-67/-l,3,4-thiadiazine 24 <1993ACS302>. The structure of this compound may be described as a skew boat form. The bond lengths C(2)-NHPr and C(2)-N(3) indicate that the amine tautomer is preferred in the solid state. Analogous results are observed for A -[5-aryl-6/7-l,3,4-thiadiazin-2-yl]2-[(phenylsulfonyl)amino]propanamides 25 <2001AXC593>. The X-ray crystal structure of the l,3,4-thiadiazino[6,5,4-r,/ ]quinoline derivative 26 has been reported <1998MC131>. 

NaH-dispersion added carefully to a soln. of 2-(benzo[b]thien-4-yloxy)-2-methyl-propanamide in dry hexamethylphosphoramide, and heated 1 hr. on a steam bath N-benzo[b]thien-4-yl-2-hydroxy-2-methylpropanamide. Y 72%. - This is a stage of a 4-step sequence for the prepn. of ar. amines from phenols. F. e. s. R. Bayles et al., Synthesis 1977, 33, 31. 

The CH2 protons in propanamide (Fig. 7) are deshielded by the adjacent carbonyl group and couple with the CHj protons to give an A Xj quartet and triplet. The resonance of the amine protons at 6.4 5/ppm is broadened by proton-proton exchange and could be removed by shaking with D2O. The integral ratios are 2 2 3. 

Synonyms N-2-Fiydroxyethyllactamide 2-Fiydroxy-N-(2-hydroxyethyl) propanamide Lactic acid monoethanolamide Lactonyl ethanol amine Lactoyl ethanola-mine Monoethanoiamine lactic acid amide Definition Mixture of ethanolamides of lactic acid Ionic Nature Nonionic Empirical CjFI NOj Formula CH3COHHCONHCH2CH2OH... 

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