Prompt - Acetaminophen

Promazettes Promazine HCI Promecon Benzquinamide Promedes Furosemide Promet Promethazine HCI Promethapar Promethazine HCI Prometin Metoclopramide HCI promexin Chlorpromazine HCI Promezerine Promazine HCI Promid Protionamide Promide Chlorpropamide promine Promethazine HCI promodor Diphenidol Promosol Chlorpromazine HCI Prompt Acetaminophen pronalgon F Dinoprost tromethamine Pronemia Folic acid Pronison Prednisone Pronoctan Lormetazepam Pronovan Propranolol HCI Prontoformin Phenformin Prontolax Bisacodyl. 

A minor asymptomatic increase in liver aminotransferase is seen in 10 to 20% of patients, whereas fatal hepatitis is seen in fewer than 1% of isoniazid recipients. Risk factors for hepatitis include underlying liver disease, advanced age, pregnancy, and combination therapy with acetaminophen. Early recognition and prompt discontinuation of the drug is recommended to prevent further damage to the liver. 

Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug that is relatively safe when taken at prescribed therapeutic doses. However, it has become increasingly common for overdoses of paracetamol to be taken for suicidal intent. In the United Kingdom, for example, around 200 deaths a year result from overdoses of paracetamol. This has prompted some to call for changes in its availability, with newspaper headlines such as "Doctors demand curbs on killer paracetamol" (Sunday Times, London, 14th November, 1993). When taken in overdoses, paracetamol causes primarily centrilobular hepatic necrosis, but this may also be accompanied by renal damage and failure. 

Acetaminophen is ordinarily safe at the recommended dosages, but large amounts exhaust the reserve of glutathione and may cause fatal liver damage. By 1989, more than 1000 cases of accidental or intentional (suicide) overdoses had been reported with many deaths. Prompt oral or intravenous administration of N-acetylcysteine over a 72-hour period promotes synthesis of glutathione and is an effective antidote.)... 

In the event of NSAID-induced renal failure, the NSAID should be discontinued promptly. The patient should receive supportive care, including temporary dialysis if needed. Beware that after stabilization of renal function, rechallenge with the same or even a structurally different NSAID is likely to reproduce the undesirable side effect. Hence, if anti-inflammatory therapy is essential, underlying risk factors should be identified and eliminated. If this is not possible, as in the case of old age or chronic kidney or liver failure, the patient may require alternative therapy using corticosteroids or other supportive drugs, such as acetaminophen and/or opioids. 

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