Promoter ubiquitin

Marchese A, Benovic JL. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 2001 276(49) 4550SM5512. 

XiE, Q., et al., SINAT5 promotes ubiquitin-related degradation of NACl to attenuate auxin signals. Nature, 2002, 419(6903), 167-70. 

The role of Skpl is to bring the substrate-targeting subunit, the F-box protein, into proximity with the Cull/Rocl/E2 complex to promote ubiquitin transfer from the E2-ubiquitin to the F-box protein-bound substrates. 

Elucidation of the structure of the SCF ubiquitin E3 ligase complex and their substrates should help resolve certain issues regarding the mechanism by which SCF E3 ligase promotes ubiquitin transfer from the E2 enzyme to the protein substrate. Recently, the structures of Cull/Rocl in complex with Skpl and Skp2, as well as that of Skpl/jS-Trcp and Cdc4, have been reported [21, 25, 55, 56]. These studies... 

O FIagan, R. C., et al., Myc-enhanced expression of Cull promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Deo, 2000, 14(17), 2185-91. 

Wu, K., Chen, A. and Pan, Z. Q. Conjugation of NeddS to CULl enhances the ability of the ROCl-CULl complex to promote ubiquitin polymerization. / Biol Chem 2000, 275, 32317-24. 

Mitochondrial dynamics (fission, fusion, migration) has been reported to play an important role in neurotransmission, synaptic stability, and maintenance and neuronal survival. PBMKl and Parkin are closely associated within the regulation of mitochondrial dynamics and function (Bueler, 2009). Mutations in DJ-1, Parkin, and PINK 1 render animals more susceptible to oxidative stress and mitochondrial toxins implicated in sporadic PD. DJ-1, Parkin, and PINKl form a complex (termed PPD complex) to promote ubiquitination and degradation of Parkin substrates, including Parkin itself and synphilin-1. In addition, mutant proteins may retard the transport of nuclear-encoded mitochondrial proteins to mitochondria, interact with mitochondrial proteins and disrupt the electron transport chain, induce free radicals, cause... 

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