Progesterone Receptor Research

Progesterone was one of the first nuclear receptor hormones for which the functional role had been elucidated and used as a drug target. It plays an important role in female reproduction, controlling ovulation and maintaining pregnancy as well as in the growth and differentiation of endometrial and myometrial cells in the uterus. 

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Ruotsalainen S, Miettinen R, MacDonald E, et al The role of the dorsal raphe-serotonergic system and cholinergic receptors in the modulation of working memory. Neurosci Biobehav Rev 22 21-31, 1998 Rupprecht R, ReulJMHM, Trapp T, et al Progesterone receptor-mediated effects of neuroactive steroids. Neuron 11 523-530, 1993 Rush AJ, Beck AT, Kovacs M, et al Comparative efficacy of cognitive therapy and pharmacotherapy in the treatments of depressed outpatients. Cognitive Therapy Research 1 17-37, 1977... 

Madauss, K.P., Stewart, E.L. and Williams, S.P. (2007) The evolution of progesterone receptor ligands. Medicinal Research Reviews, 27, 374-400. 

Warner, M., Hayashi, Y., Horiguchi, S., Watanabe, T., Hayashi, S., Gustafsson, J.A. and Toi, M. (2002) Expression of estrogen receptor (ER) [lex protein in ERa-positive breast cancer specific correlation with progesterone receptor. Cancer Research, 62, 4849-4853. 

McGowan, E.M., Saad, S., Bendall, L.J., Bradstock, K.F. and Clarke, C.L. (2004) Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts. Breast Cancer Research and Treatment, 83, 211-220. 

Klaus Schollkopf and Norbert Schmees give an overview of the biology of the progesterone receptor and of the development of research in the field of steroidal progestins and recent trends in discovery of nonsteroidal selective progesterone receptor modulators. 

Anti-ferti1i ty - The potential of steroids in the anti-fertility area is probably still the leading motivation for research in this field, but little new information has appeared. Two steroids, oxymetholone and nandrolone phenpropionate, both well established anabolic agents, were shown to cause resorption of fetuses after implantation. The term "Inter-ceptives" was proposed for this type of effect. This action of both compounds could be reversed by progesterone. It was postulated that oxymeth-olone suppresses pituitary gonadotrophin release, while nandrolone phenpropionate either inhibits luteal synthesis of progesterone or competitively blocks a uterine receptor site necessary for pregnancy maintenance. ... 

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