Proelectrophile mechanism

Lipnick, R.L., Watson, K.R. and Strausz, A.K. (1987) A QSAR study of the acute toxicity of some industrial organic chemicals to goldfish. Narcosis, electrophile and proelectrophile mechanisms. Xenobiotica, 17,... 

Proelectrophile Mechanism. Proelectrophiles, which produce electrophiles by means of metabolic transformation, represent a second class... 

Figure 6. Schematic representation of the physiological and biochemical processes involved in the production of lethality to fish from toxicants acting by narcosis, electrophile, and proelectrophile mechanisms.

R.L. Lipnick (1989b). Narcosis, electrophile, and proelectrophile toxicity mechanisms. Application of SAR and QSAR. Environ. Toxicol. Chem., 8, 1-12... 

Narcosis represents the most fundamental mechanism of the toxicity of nonelectrolyte organic compounds, and corresponds to minimum or baseline toxicity. Quantitative structure-activity relationships for chemicals acting by this mechanism for various organisms and routes of exposure provide a valuable probe for determining whether or not a candidate chemical acts via narcosis or by an electrophile, proelectrophile, cyanogenic, or other more specific molecular mechanism. 

The second experiment we present in this tutorial for classifying compounds according to their mechanism of action involves the classifications of 88 chemicals. The chemicals are either narcotics (nonpolar and polar narcotics) and reactive compounds (respiratory uncouplers, soft electrophiles, and proelectrophiles).The dataset, consisting of 48 narcotic compounds... 

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