Production of 6,12-Dihydro-6-hydroxy-cannabidiol

It is an advantage in the method in accordance with the invention that starting with readily available materials the intermediate product in the form of 6,12-dihydro-6-hydroxy-cannabidiol may be produced simply with a good yield and that such product may be purified without any great difficulty. [Pg.56]

Starting with the intermediate product in accordance with the invention it is possible to obtain highly pure, that is to say low-isomer A THC, the purification of the THC so obtained being possible by simple elution of a silica gel column. With the aid of the method described above it is possible to achieve a high, reproducible 3deld of the A9-THC and the production of the final product is also possible on an industrial scale. [Pg.56]

90 g of olivetol were agitated with 85 g of cis-p-menth-2-ene-l,8,-diol and 4 g of p-toluenesulfonic acid H20 in 4 L. methylene chloride for 24 hours at 20° C. Then extraction was performed once with 200 mL.. of 4% calcium carbonate solution and the organic phase was reduced in vacuum to an oil. In this respect approximately 170 g of residue were obtained, which were dissolved in 1 L of petroleum ether (50/70) and extracted three times with respectively 300 mL. of 0.5 N sodium hydroxide. [Pg.56]

The petroleum ether phase was then run into a silica gel column (approximately 500 g of silica gel) and eluted with a mixture of petroleum ether (50/70) and diisopropylether (2 1). The eluate was reduced in volume under vacuum and the residue (approximately 102 g) was recrystallized from 600 mL of petroleum ether (50/70). 77 g of the desired product were obtained. The characteristic data of the 6,12-dihydro-6-hydroxy-cannabidiol were as follows Fusion point 77° to 77.5° C. [Pg.56]

10 g of 6,12-dihydro-6-hydroxy-cannabidiol were dissolved in 300 mL of methylene chloride and held for 24 hours under reflux in the [Pg.56]

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