Production of Anticancer Drugs in Microbial Hosts

1 Georgiev, M.I., Weber, J., and Maciuk, A. (2009) Bioprocessing of plant cell cultures for mass production of targeted compounds. Appl. Microbiol. Biotechnol., 83, 809-823. 

2 Roberts, S.C. (2007) Production and engineering of terpenoids in plant cell culture. Nat. Chem. Biol., 3, 387-395. 

(2009) Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. J. Am. Chem. Soc., 131, 4904-4916. 

7 Balandrin, M.F., Kinghorn, A.D., and Farnsworth, N.R. (1993) Plant-derived natural-products in drug discovery and development — an overview. ACS Symp. Sen, 534, 2-12. 

8 DiCosmo, F. and Misawa, M. (1995) Plant cell and tissue culture alternatives for metabolite production. Biotechnol. Adv., 13, 425-453. 

---