Product prediction strategies

Too little maintenance results in unexpected failures and consequential major losses of production and/or customers (Figure 7-1). This impractical approach is termed reactive strategy and should be avoided on all important machinery. Optimum maintenance strategy balances reasonable costs with maximum possible availability and reliability. The two main maintenance strategies employed by companies today are labelled predictive strategy and preventive strategy. These are part of a balanced approach as shown in Figure 7-2. 

In instances where test bores have been completed, it may sometimes be possible to predict the general locations of productive fractures. When these are encountered by surprise, however, the appropriate adjustments in the drilling strategy must be implemented rapidly, slowing the progress of the drilling operation and increasing the costs. 

Strategy When predicting the product of a reaction, you have to recall what you know about the kind of reaction being carried out and then apply that knowledge to the specific case you re dealing with. In the present instance, recall that the two methods of... 

Polymer production technology involves a diversity of products produced from even a single monomer. Polymerizations are carried out in a variety of reactor types batch, semi-batch and continuous flow stirred tank or tubular reactors. However, very few commercial or fundamental polymer or latex properties can be measured on-line. Therefore, if one aims to develop and apply control strategies to achieve desired polymer (or latex) property trajectories under such a variety of conditions, it is important to have a valid mechanistic model capable of predicting at least the major effects of the process variables. 

The volume is divided into five sections. Part one looks at the experimental study of membrane permeability and oral absorption. In Part two, problems of measuring and prediction solubility, as one of the key determinants in the absorption process, will be discussed in detail. In the next part, progress in the science around transporter proteins and gut wall metabolism and their effect on the overall absorption process is presented. Part four looks at the in silico approaches and models to predict permeability, absorption and bioavailability. In the last part of the book, a number of drug development issues will be highlighted, which could have an important impact of the overall delivery strategies for oral pharmaceutical products. 

---