Product development pipeline management

The two enterprise-wide decision problems that have received lately most attention have been SCM and product development pipeline management (PDPM). SCM addresses the design and operational issues associated with the network with which an enterprise delivers its products to the marketplace, while PDPM addresses the set of decisions associated with turning a new discovery into a product and introducing it into the corporation s SC (Varma et al. 2007). Their successful solution has a direct impact on the viability of the enterprise. Ideally, all these decisions need to be coordinated. However, this is often not the case, leading to suboptimal portfolios and ineffective utilization of capital and R D resources (Varma et al. 2007). 

The Optimal Condition Decomposition (OCD), which is a particular case of the Lagrangian relaxation procedure, is applied to overcome the computational cost of solving the monolithic problem, which integrates SC design-retrofitting and product development pipeline management formulations. Further details about this decomposition strategy can be found in Appendix A.7.1. 

Techniques for coordinating new product development and supply chain management the approaches cover both existing and new product pipelines... 

The core component of the oil supply chain is the refinery, where the received oil batches are managed to feed the crude distillation units in proportions that give origin to the desired cuts and products. However, the oil supply and the oil products distribution have to answer in agreement to their predicted demands. For this reason, fliere is the need to build decision support tools to manage inventory distribution. This work focuses on the development of a MILP model that describes the oil products distribution through a pipeline that connects one refinery to one tank farm. In order to supply die local market, the model represents the interaction between the pipeline schedule and the internal restrictions at the tank farm. Real world data from CLC (a Portuguese company) validate the model formulation. 

Process development follows an overall development plan that coordinates all the various disciplines involved. It is typically performed in three cycles to allocate resources and thus manage product pipelines efficiently, and involves a scale-up of up to 1000-fold and more [128]. During the exploratory phase, a research method is used to generate small amounts of the respective MAbs to investigate target-specific effects in-vitro. Important technical goals at this stage are feasibility and speed. 

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