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Prodrugs dextran

Probably the most promising polymeric drug carrier system involves polysaccharide molecules. These are natural polymers and are often biodegradable to products that are useful to the host or easily eliminated by the host. Dextrans have been the most extensively used polysaccharide for macromolecular prodrug preparations (79). These materials are biocompatible and the in vivo fate is directly related to their molecular weight. Moreover these macromolecules can be easily targetted to the hepatocytes with D-mannose or L-fucose (20). [Pg.14]

F Harboe, C Larsen, MJ Johansen, HP Olesen. Macromolecular prodrugs. XV. Colon-targeted delivery—Bioavailability of naproxen from orally administered dextran-naproxen ester prodrugs varying in molecular size in the pig. Pharm Res 6(11) 919—923, 1989. [Pg.230]

R. Mehvar, D. A. Hoganson, Dextran-Methylprednisolone Succinate as a Prodrug of Methylprednisolone Immunosuppressive Effects after in vivo Administration to Rats ,... [Pg.550]

DESIGN OF MACROMOLECULAR PRODRUG OF CISPLATIN ATTACHED TO DEXTRAN THROUGH COORDINATE BOND... [Pg.7]

Design of Macromolecular Prodrug of Cisplatin Attached to Dextran through Coordinate Bond... [Pg.243]

Macleod, A.D., Tolentino, L., and Tozer, T.N., Glucocorticoid-dextran conjugates as potential prodrugs for colon-specific delivery steady-state pharmacokinetics in the rat, Biopharm. DrugDisp., 15 151-161 (1994). [Pg.58]

McLeod, A. D., D. R. Friend, andT. N.Tozier. 1993. Synthesis and chemical stability of glucocorticoid-dextran esters potential prodrugs for colon-sped c delivloilyJ. Pharm.92 105-114. [Pg.464]

Polymeric prodrugs are currently one of the most investigated topics. This research has resulted in breakthrough therapeutics, and many compounds are under clinical development (Table 3.7). Other examples of polymeric prodrug applications include the use of polysaccharides such as dextran, mannan, and pullulan to enable active targeting to tumor cells.117... [Pg.97]

A. D. McLeod, Dextran prodrugs for colon-specific drug delivery, Chapter 8 (D. R. Friend, ed.), Oral Colon-specific Drug Delivery, CRC Press, Boca Raton, 1992, pp. 214-231. [Pg.56]

C. Larsen, E. Harboe, M. Johansen, and H. P. Olesen, Macromolecular prodrugs Naproxen-dextran esters, Pharm. Res. 6 919-923, 995-999 (1989). [Pg.56]

Synthesis of Dextran Esters with Bioactive Moieties (Prodrugs)... [Pg.199]

Keywords Functionalised dextran Structural analysis Prodrugs Nanostructures Bioactivity... [Pg.200]

Conversion of dextran in DMF/IiCl with succinic anhydride is a popular method for the introduction of spacer-bound large molecules [171,172]. Moreover, homogeneous esterification is exploited for the binding of bioactive compounds yielding prodrugs and for the introduction of unsaturated moieties giving precursors for hydrogels as discussed in the next sections. [Pg.230]

See other pages where Prodrugs dextran is mentioned: [Pg.73]    [Pg.207]    [Pg.550]    [Pg.244]    [Pg.47]    [Pg.37]    [Pg.452]    [Pg.452]    [Pg.463]    [Pg.392]    [Pg.37]    [Pg.48]    [Pg.48]    [Pg.49]    [Pg.200]    [Pg.233]    [Pg.233]    [Pg.234]    [Pg.235]    [Pg.237]    [Pg.237]    [Pg.263]    [Pg.206]    [Pg.377]    [Pg.1233]    [Pg.132]    [Pg.378]    [Pg.39]    [Pg.39]    [Pg.40]   
See also in sourсe #XX -- [ Pg.1233 ]



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Colonic targeting dextran prodrugs

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