Prodrugs polymeric

The discovery of monoclonal antibodies and combining them with polymeric prodrugs is the newest approach to overcome the lack of selectivity for disposition in target tissue (23). Recently the selectivity of antibody-targeted polymeric anthracycline antibiotics to T lymphocytes was accomplished (25). In addition decreased immunogenicity of proteinaceous conjugates with IgG and human transferrin has been reported (26). 

Polymeric peroxides, 18 442, 480 Polymeric prodrugs, 9 80 Polymeric resins... 

Yang, L., Chen, L., Zeng, R., Li, C, Qiao, R., Hu, L., and Li, Z. (2010). Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug Chitosan-O-isopropyl-50-O-d4T monophosphate conjugate. Bioorg. Med. Chem. 18,117-123. 

Polymeric prodrugs are currently one of the most investigated topics. This research has resulted in breakthrough therapeutics, and many compounds are under clinical development (Table 3.7). Other examples of polymeric prodrug applications include the use of polysaccharides such as dextran, mannan, and pullulan to enable active targeting to tumor cells.117... 

Figure 3.17 Polymeric prodrug with PEG carrier and lysine linker.

The antitumor activity of synthetic 5-FU derivatives, polymeric prodrugs having 5-FU unit, and physically 5-FU incorporated polymers has been investigated [44-55], Moreover recent attention has been focused on syntetic polyanionic polymers [41], and drug-polyanion conjugates have been prepared to evaluate the activities [56],... 

Angewandte Makromolelmlare Chentie Vol.245, March 1997, p.1-8 POLYMERIC PRODRUGS SYNTHESIS, RELEASE STUDY AND ANTIMICROBIAL PROPERTIES OF POLYMER-BOUND ACRIFLAVINE... 

Design and development of novel polymeric prodrugs prepared by mechano-chemical solid-state polymerization 00YZ1337. 

Proteins such as serum albumin have also been frequently used for preparing polymeric prodrugs. An... 

Giammona, G., Puglisi, G., Carlisi, B., Pignatello, R., Spadaro, A. and Caruso, A. (1989) Polymeric prodrugs a-P-poly(N-hydroxyethyl)-DL-aspartamide as macromolecular carrier for some non-steroidal antiinflammatory agents. Int. J. Pharm. 57 55-62. 

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